Leukotriene D4-d5 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Leukotriene D
4-d
5 (LTD
4-d
5) is intended for use as an internal standard for the quantification of LTD
4 by GC- or LC-MS. LTD
4 is an active metabolite of LTC
4 (Item Nos.
20210 |
10007241) and a constituent of slow-reacting substance of anaphylaxis (SRS-A). It is formed
via metabolism of LTC
4 by γ-glutamyl transpeptidase. Like LTC
4, LTD
4 (0.01-0.1 pM) induces contractions in isolated guinea pig parenchymal strips and tracheal spirals.
In vivo, LTD
4 increases insufflation pressure, a marker of bronchoconstriction, in anesthetized guinea pigs by 100% when administered at a dose of 89 pmol per animal. It also increases vascular permeability in guinea pig skin when administered intradermally at a dose of 0.1 pmol per animal.
Leukotriene D4-d5 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte