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(±)-JQ1

(±)-JQ1 Struktur
1268524-69-1
CAS-Nr.
1268524-69-1
Englisch Name:
(±)-JQ1
Synonyma:
rac JQ-1;(+/-)-JQ1;(+/-)-SGCBD01;tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate;[(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester;6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester;tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11 ,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,1 2-pentaen-9-yl]acetate
CBNumber:
CB62589817
Summenformel:
C23H25ClN4O2S
Molgewicht:
456.99
MOL-Datei:
1268524-69-1.mol

(±)-JQ1 Eigenschaften

Siedepunkt:
610.4±65.0 °C(Predicted)
Dichte
1.33±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
L?slichkeit
DMSO: soluble2mg/mL, clear (warmed)
pka
2.05±0.60(Predicted)
Aggregatzustand
powder
Farbe
white to beige
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Sicherheit

WGK Germany  3

(±)-JQ1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(±)-JQ1 has been used to study its effect on adipogenesis, by analysing the its impact on the regulation of genes involved in this process especially peroxisome proliferator-activated receptor (PPAR-g), the CCAAT/enhancer-binding protein (C/EBPa) and, STAT5A and B. JQ1 has been used in drug binding assays as a chemical inhibitor of BRD4 to study the CRBN′s substrate recruiting function in mouse and human.

Biochem/physiol Actions

(±)-JQ1 is a Brd4 inhibitor. JQ1 is known to suppress cell proliferation and therefore, can be used as a therapeutic drug for a number of cancers including multiple myeloma and acute myeloid leukemia.

(±)-JQ1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate

(±)-JQ1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 25)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Accela ChemBio Inc. 		+1-858-6993322
info@accelachem.com United States 17777 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Taizhou Tongxin Bio-Tech Co., Ltd 0523-18601685-898 18652728585
 sales@allyrise.com China 2782 60
Shanghai YuanQi Biotechnology Co., Ltd. +86-2332782371 +86-18120098618
 sales@adobechem.com China 1250 50
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51456 80
Taizhou Ruixin Chemical Co., Ltd. 0576-89085261 15867635987
 jasonhu09@163.com China 442 50
Shanghai Chaolan Chemical Technology Center 021-QQ：65489617 15618227136
 Sales@ATKchemical.com China 7296 58
  • [(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester
  • tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
  • (+/-)-SGCBD01
  • rac JQ-1
  • 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester
  • (+/-)-JQ1
  • tert-butyl 2-[7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11 ,12-tetraazatricyclo[8.3.0.0,2,6]trideca-2(6),4,7,10,1 2-pentaen-9-yl]acetate
  • 1268524-69-1
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