1-(3-Methoxypropyl)-4-piperidinamine
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- CAS-Nr.
- 179474-79-4
- Englisch Name:
- 1-(3-Methoxypropyl)-4-piperidinamine
- Synonyma:
- Prucalopride intermediateB;4-AMino-1-(3-Methoxypropy...;Prucalopride Succinate iMpuritO;3-methoxy propyl piperidinamine;1-(3-methoxypropyl) -4-piperidine;1-(3-Methoxypropyl)-4-piperidimine;1-(3-Methoxypropyl)-4-piperidinamine;1-(3-Methoxypropyl)piperidin-4-aMine;Prucalopride Succinate interMediate B;4-AMino-1-(3-Methoxypropyl)piperidine
- CBNumber:
- CB62589756
- Summenformel:
- C9H20N2O
- Molgewicht:
- 172.27
- MOL-Datei:
- 179474-79-4.mol
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1-(3-Methoxypropyl)-4-piperidinamine Eigenschaften
- Siedepunkt:
- 249℃
- Dichte
- 0.946
- Flammpunkt:
- 105℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- Chloroform (Slightly), Methanol (Slightly)
- Aggregatzustand
- Oil
- pka
- 10.49±0.20(Predicted)
- Farbe
- Colourless to Pale Yellow
- InChI
- InChI=1S/C9H20N2O/c1-12-8-2-5-11-6-3-9(10)4-7-11/h9H,2-8,10H2,1H3
- InChIKey
- HIXAJGFVNMKLML-UHFFFAOYSA-N
- SMILES
- N1(CCCOC)CCC(N)CC1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
1-(3-Methoxypropyl)-4-piperidinamine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
1-(3-Methoxypropyl)-4-piperidinamine is a useful synthetic intermediate in the synthesis of Prucalopride Succinate (P838950); a selective 5-HT4 receptor agonist used effective for chronic constipation, but is not currently approved in the U.S. Prucalopride is approved for the treatment of chronic constipation in Europe.
Synthese
N-(1-(3-methoxypropyl)piperidin-4-yl)acetamide (10.72g, 0.05mol) was added to HCl-methanol solution (0.5M, 180ml), and the temperature was controlled at 2025°C After the reaction was detected, it was filtered, and the filter cake was washed with dichloromethane and dried to obtain 1-(3-Methoxypropyl)-4-piperidinamine with a yield of 96.4% and a purity of 99.7%.
1-(3-Methoxypropyl)-4-piperidinamine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-(3-Methoxypropyl)-4-piperidinamine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 166)Lieferanten
- 1-(3-Methoxypropyl)-4-piperidinamine
- 4-AMino-1-(3-Methoxypropyl)piperidine
- 4-AMino-1-(3-Methoxypropy...
- 4-PiperidinaMine, 1-(3-Methoxypropyl)-
- 1-(3-Methoxypropyl)piperidin-4-aMine
- Prucalopride Succinate interMediate B
- 1-(3-Methoxypropyl)-4-piperidimine
- Prucalopride intermediateB
- 1-(3-Methoxypropyl)-4-piperidinamine (Plucabili impurity)
- PRUCALOPRIDE SUCCINATE CAS 179474-85-2 INTERMEDIATES
- Prucalopride Succinate iMpuritO
- 3-methoxy propyl piperidinamine
- 1-(3-methoxypropyl) -4-piperidine
- 1- (3-methoxypropyl) -4-piperidine amine
- 179474-79-4
- 179474-97-4
