ICG-001 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
(S,S)-ICG 001 is a β-turn peptidomimetic molecule inhibitor of β-catenin-Tcf-mediated transcription.
Allgemeine Beschreibung
A cell-permeable pyrazinopyrimidinecarboxamide that competes against β-catenin for CBP (CREB-binding protein) binding and selectively prevents CBP- but not p300-, dependent TCF/β-catenin transcriptional regulations both in cultures
in vitro (5 to 25 μM) and in mice
in vivo (5 mg/kg/day via osmotic pump infusion), while not affecting CBP-dependent transcriptional activities mediated by the AP-1 or CRE complex. Shown to reactivate p300//TCF/β-catenin-mediated neuronal differentiation upon NGF stimulation in PS-1 L286V mutant-expressing PC-12 cultures and be efficacious in alleviating bleomycin- (0,08 units/50 μL/mouse; administered intranasally; Cat. No.
203401) induced pulmonary fibrosis in mice.
Biochem/physiol Actions
Cell permeable: yes
ICG-001 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
