7-hydroxy-2-methyl-4H-chromen-4-one
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- CAS-Nr.
- 6320-42-9
- Englisch Name:
- 7-hydroxy-2-methyl-4H-chromen-4-one
- Synonyma:
- NSC 31894;Hymecromone EP Impurity B;7-Hydroxy-2-methylchromone;7-hydroxy-2-methylchromen-4-one;7-Hydroxy-2-methyl-4H-1-benzopyran-;7-hydroxy-2-methyl-1-benzopyran-4-one;7-Hydroxy-2-Methyl-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 7-hydroxy-2-Methyl-;Hymecromone Impurity 2 (Hymecromone EP Impurity B)
- CBNumber:
- CB62490146
- Summenformel:
- C10H8O3
- Molgewicht:
- 176.17
- MOL-Datei:
- 6320-42-9.mol
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7-hydroxy-2-methyl-4H-chromen-4-one Eigenschaften
- Schmelzpunkt:
- 254-255℃
- Siedepunkt:
- 345.5±42.0 °C(Predicted)
- Dichte
- 1.319±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- pka
- 7.07±0.40(Predicted)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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7-hydroxy-2-methyl-4H-chromen-4-one Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
7-Hydroxy-2-methyl-4H-chromen-4-one is used in the synthesis of 2,2-Dimethyl-2H-pyranoflavonol and pyranochromone derivatives.
Synthese
Step(i): 7-Acetoxy-3-acetyl-2-methylchromone
β-Resacetophenone (4.A.6) (10 g，0.066 mole) is heated with fusedsodium acetate (20 g) in acetic anhydride (30 ml) for 5 hr at 170-180°(oil bath) under anhydrous conditions. The reaction mixture is pouredover crushed ice, stirred well and left overnight.The separated product isfiltered and washed with water. It is crystallised from alcohol as light yellowneedles.Yield 10 g (58.5%).M.p.127° (lit. m.p.126-27°).
step (ii) : The above 7-acetoxy-3-acetyl-2-methylchromone (1 g,0.0038 mole) isrefluxed (2 hr) with aqueous sodium carbonate solution (10%,50 ml).Theclear solution is then acidified with hydrochloric acid (1:1).The separatedproduct is filtered and washed with water. It is crystallised from alcohol asthick prismatic crystals. Yield 0.5 g (73.5%).M.p. 249-50°.(lit. m.p.254-55°).
7-hydroxy-2-methyl-4H-chromen-4-one Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
7-hydroxy-2-methyl-4H-chromen-4-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 37)Lieferanten
- NSC 31894
- 7-Hydroxy-2-Methyl-4H-1-benzopyran-4-one
- 4H-1-Benzopyran-4-one, 7-hydroxy-2-Methyl-
- 7-Hydroxy-2-methylchromone
- 7-hydroxy-2-methylchromen-4-one
- Hymecromone Impurity 2 (Hymecromone EP Impurity B)
- Hymecromone EP Impurity B
- 7-Hydroxy-2-methyl-4H-1-benzopyran-
- 7-hydroxy-2-methyl-1-benzopyran-4-one
- 6320-42-9
