Tigecycline
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Tigecycline Eigenschaften
- Schmelzpunkt:
- 164-166°C
- Siedepunkt:
- 890.9±65.0 °C(Predicted)
- Dichte
- 1.45±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- L?slichkeit
- Soluble in DMSO (up to at least 25 mg/ml).
- pka
- 4.50±1.00(Predicted)
- Aggregatzustand
- Orange powder
- Farbe
- Orange
- Merck
- 14,9432
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
- InChIKey
- FPZLLRFZJZRHSY-HJYUBDRYSA-N
- SMILES
- C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C(N(C)C)=CC(NC(CNC(C)(C)C)=O)=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O
- CAS Datenbank
- 220620-09-7(CAS DataBase Reference)
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
S-S?tze: | 24/25 | ||
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RIDADR | 3077 | ||
RTECS-Nr. | QI7619500 | ||
HazardClass | 9 | ||
PackingGroup | III | ||
HS Code | 29419090 | ||
Giftige Stoffe Daten | 220620-09-7(Hazardous Substances Data) |
Bildanzeige (GHS) | |||||||||||||||||||||||||||||
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Alarmwort | Achtung | ||||||||||||||||||||||||||||
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Sicherheit |
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Tigecycline Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The emergence of drug-resistant bacteria has diminished the clinical utility of the
tetracyclines. Research to circumvent the efflux and ribosomal protection mechanisms
of bacteria has led to the development of the glycylcyclines. Tigecycline is
the first glycylcycline antibiotic to launch for the parenteral treatment of
baterial infection, including complicated intra-abdominal and skin infections. Its mechanism of action involves inhibiting protein translation in bacteria by binding
to the 30S ribosomal subunit and blocking entry of amino-acyl tRNA molecules
into the A site of the ribosome to effectively prevent incorporation of amino acid
residues into elongating peptide chains. Presumably, ribosomal protection proteins
are ineffective against tigecycline due to its higher affinity for ribosomal binding
compared to tetracyclines (approximately 16-fold). In addition, tigecycline may be
resistant to efflux mechanisms by either their inability to translocate it across the
cytoplasmic membrane due to steric complications or simply by their failure to
recognize the molecule.
Chemische Eigenschaften
Orange SolidVerwenden
Tigecycline is a semi-synthetic tetracycline prepared by the introduction of a tert-butylaminoacetamido group into a previously unexplored and un-substituted region of existing tetracyclines. Like other tetracyclines, tigecycline acts by reversibly binding to the 30S ribosomal subunit and inhibits protein translation by blocking entry of aminoacyl-tRNA into the ribosome A site. The enhanced activity can be attributed to stronger binding affinity, thus minimising the impact of existing mechanisms of resistance. Tigecycline is regarded as the first of a new class of glycylcyline antibiotics. Critical comparison to the tetracycline class appears to be lacking in the literature.Definition
ChEBI: Tetracycline in which the hydroxy group at position 5 and the methyl group at position 6 are replaced by hydrogen, and with a dimethylamino substituent and an (N-tert-butylglycyl)amino substituent at positions 7 and 9, respe tively. A glycylcycline antibiotic, it has activity against a broad range of Gram-positive and Gram-negative bacteria, including tetracycline-resistant organisms. It is used for the intravenous treatment of complicated skin and skin structure infections ca sed by susceptible organisms.Antimicrobial activity
It is as potent as, or more potent than, earlier tetracyclines and activity is retained against strains expressing acquired tetracycline resistance determinants. It displays better activity than tetracycline, doxycycline or minocycline against Streptococcus spp. and against Enterococcus faecalis and E. faecium. Among Gram-negative organisms it displays improved activity against Citrobacter freundii, Escherichia coli, Enterobacter cloacae, Klebsiella pneumoniae, Salmonella spp., Serratia marcescens and Shigella spp. The spectrum includes rapidly growing mycobacteria. Ps. aeruginosa, Pr. mirabilis, other Proteus spp. and some strains of Corynebacterium jeikeium are resistant. Activity against strains expressing acquired resistance to earlier tetracyclines is attributed to failure of the MFS efflux pumps to recognize tigecycline, and to a novel mechanism of ribosome binding that permits tigecycline to overcome ribosomal protection mechanisms.Comparative susceptibility data for some atypical pathogens are not available. However, in common with earlier tetracyclines, it is active against Chlamydophila and Mycoplasma spp. and rapidly growing Mycobacteria spp. It is less active than minocycline or tetracycline against U. urealyticum.
Allgemeine Beschreibung
Tigecycline (Tygacil) is a first-in-class (a glycylcycline) intravenousantibiotic that was designed to circumvent manyimportant bacterial resistance mechanisms. It is not affectedby resistance mechanisms such as ribosomal protection, effluxpumps, target site modifications, β-lactamases, or DNAgyrase mutations. Tigecycline binds to the 30S ribosomalsubunit and blocks peptide synthesis. The glycylcyclinesbind to the ribosome with five times the affinity of commontetracyclines. Tigecycline also possesses a novel mechanismof action, interfering with the mechanism of ribosomal protectionproteins. Tigecycline, unlike common tetracyclines,is not expelled from the bacterial cell by efflux pumpingprocesses.Tigecycline is recommended for the treatment of complicatedskin and skin structure infections caused by E. coli,E. faecalis (vancomycin-susceptible isolates), S. aureus(methicillin-susceptible and methicillin-resistant isolates),S. pyogenes, and B. fragilis among others. Tigecycline is alsoindicated for complicated intra-abdominal infections causedby strains of Clostridium, Enterobacter, Klebsiella, andBacteroides. To reduce the development of resistance to tigecycline,it is recommended that this antibiotic be used onlyfor those infections caused by proven susceptible bacteria.Glycylcyclines are structurally similar to tetracyclines,and appear to have similar adverse effects. These mayinclude photosensitivity, pancreatitis, and pseudotumorcerebri. Nausea and vomiting have been reported.
Pharmazeutische Anwendungen
9-T-butylglycylamido-minocycline. A compound of the glycylcycline class available as a powder for intravenous infusion.Pharmakokinetik
Cmax 100 mg intravenous infusion (1 h): 0.85–1 mg/LPlasma half-life: 37–67 h
Volume of distribution: 7–10 L/kg
Plasma protein binding: 68%
Distribution and excretion
It is widely distributed and is concentrated in the gallbladder, colon and lung. The volume of distribution is dose related and variable, but is generally greater than that of older tetracyclines. CSF penetration is poor. Tigecycline is excreted in the feces and urine predominantly as the unchanged molecule. The elimination half-life is long (37–67 h). Tigecycline clearance is decreased by 20% in patients with renal failure. No dosage adjustments are apparently necessary for tigecycline in patients with renal impairment.
Clinical Use
Complicated skin and skin structure infectionsComplicated intra-abdominal infections
Community-acquired bacterial pneumonia
Recommended principally for the treatment of infections with multiresistant organisms.
Nebenwirkungen
Side effects typical of the group, including nausea, vomiting, diarrhea and headache, occur. Occasional cases of pancreatitis, hypoproteinemia, antibiotic-associated colitis and thrombocytopenia have also been reported.Tigecycline Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Tigecycline Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Senova Technology Co. Ltd. | +86-0755-86703119 +8618503098836 |
info@senovatech.com | China | 351 | 58 |
Beijing Hope Pharmaceutical Co., Ltd. | +86-010-67886402 +8613611125266 |
market@hopelife.cn | China | 72 | 58 |
Hebei Weibang Biotechnology Co., Ltd | +8615531157085 |
abby@weibangbio.com | China | 8807 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +86 13288715578 +8613288715578 |
sales@hbmojin.com | China | 12834 | 58 |
Shaanxi TNJONE Pharmaceutical Co., Ltd | +8618092446649 |
sarah@tnjone.com | China | 1143 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 |
sales@capot.com | China | 29791 | 60 |
Nanjing Gold Pharmaceutical Technology Co. Ltd. | 025-84209270 15906146951 |
CHINA | 115 | 55 | |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21634 | 55 |
Hangzhou FandaChem Co.,Ltd. | +8615858145714 |
FandaChem@Gmail.com | China | 9080 | 55 |
Lianyungang happen teng technology co., LTD | 15950718863 |
wang666xt@163.com | CHINA | 295 | 58 |
220620-09-7()Verwandte Suche:
- 2-NAPHTHACENECARBOXAMIDE, 4,7-BIS(DIMETHYLAMINO)-9-[[[(1,1-DIMETHYLETHYL)AMINO]ACETYL]AMINO]-1,4,4A,5,5A,6,11,12A-OCTAHYDRO-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-, (4S,4AS,5AR,12AS)-
- tigecycline
- TIGECYCLINE GLYCYLCYCLINE
- (4S,4As,5aR,12as)-4,7-Bis(dimethylamino)-9-{(tert-butylamino)acetamido}-3,10,12,12a-octahydrotetracen-2-carboxamide
- 2-NAPHTHACENECARBOXAMIDE
- TIGECYCLINE POWDER
- Tegecycline
- (4S,4aS,5aR,12aS)-9-(2-(tert-butylaMino)acetaMido)-4,7-bis(diMethylaMino)-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxaMide
- Tigercycline
- (4S,4aS,5aR,12aS)-4,7-Bis(diMethylaMino)-9-[[2-[(1,1-diMethylethyl)aMino]acetyl]aMino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxaMide
- Glycylcycline
- WAY-GAR 936
- Tigecycline (WS)
- Tigecycline,tygacil
- Glycylcycline, GAR 936, 9-t-ButylglycylaMidoMinocycline
- Tigecycline (4S,4aS,5aR,12aS)-4,7-Bis(dimethylamino)-9-[(tert-butylamino)acetamido]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-carboxamide
- Tigilcycline, Tigecycline, WAY-GAR-936, GAR-936, TBG-MINO, Tygacil
- 2-NaphthacenecarboxaMide, 4,7-bis(diMethylaMino)-9-[[2-[(1,1-diMethylethyl)aMino]acetyl]aMino]-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-
- Tigecycline, >=99%
- (4S,4AS,5aR,12aS)-9-(2-(tert-butylamino)acetamido)-4,7-bis(dimethylamino)-3,10,12,12a-tetrahyd
- 9-t-Butylglycylamido-minocycline
- Tigecycline 99.9% GMP or 99.8%
- ecycL
- Tig
- Tigecycline - CAS 220620-09-7 - Calbiochem
- Tigecycline Impurity I
- CS-131
- GAR-936;TYGACIL
- (4R,4aR,5aS,12aR)-9-(2-(tert-butylamino)
- Tigecycline CRS
- Tigilcycline
- TigecycL
- igecycline
- 9-tert-Butylglycylamidominocycline
- Tigecycline USP/EP/BP
- Tigecycline (Y0001961)
- Tigecycline D9Q: What is Tigecycline D9 Q: What is the CAS Number of Tigecycline D9 Q: What is the storage condition of Tigecycline D9 Q: What are the applications of Tigecycline D9
- TigecyclineQ: What is Tigecycline Q: What is the CAS Number of Tigecycline Q: What is the storage condition of Tigecycline Q: What are the applications of Tigecycline
- Tigecycline (INTERNATIONAL COLD CHAIN SHIPMENT REQUIRED) (1667643)
- (4s,4as,5ar,12as)-4,7-bis(dimethylamino)-9-[(tert-butylamino)acetamido]-3,10,12,12a-tetrahydroxy-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracen-2-carboxamide
- Tygacil
- 2H9]-Tigecycline
- (4S,4aS,5aR,12aR)-9-[[2-(tert-butylamino)acetyl]amino]-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide
- Tigecycline (GAR-936)
- 220620-09-7
- 20620-09-7
- C29H39N5O8
- pharmaceutical intermediate
- Amines
- Chiral Reagents
- Intermediates & Fine Chemicals
- Pharmaceuticals
- API
- Antibacterial
- BDO
- 220620-09-7