BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330
Mund ausspülen.
P501
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.
In September 2013, Health Canada approved riociguat (also referred to as BAY 63-2521), for the treatment of patients with chronic thromboembolic pulmonary hypertension (CTEPH) after surgical treatment or inoperable CTEPH and for the treatment of adults with pulmonary arterial hypertension (PAH). Riociguat has a dual mode of action and works by (a) sensitizing sGC to the body’s NO by stabilizing NO–sGC binding and (b) an NO-independent, direct stimulation of sGC via a different binding site. This process restores the NO–sGC–cGMP pathway and leads to increased generation of cGMP with subsequent vasodilation. Headache, dizziness, dyspepsia/gastritis, nausea, diarrhea, hypotension, vomiting, anemia, gastroesophageal reflux, and constipation were the most common adverse events ( 3%) observed during riociguat clinical trials. Riociguat comes with a black box warning for embryo-fetal toxicity.
Chemische Eigenschaften
Brownish Orange Solid
Verwenden
Riociguat is used in the treatment for pulmonary hypertension.
Definition
ChEBI: A carbamate ester that is the methyl ester of {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}methylcarbamic acid. It is used for treatment of chronic thromboembolic pulmonary hypertension an
pulmonary arterial hypertension
Riociguat Upstream-Materialien And Downstream Produkte
Riociguat 13CD3Q: What is
Riociguat 13CD3 Q: What is the CAS Number of
Riociguat 13CD3 Q: What is the storage condition of
Riociguat 13CD3 Q: What are the applications of
Riociguat 13CD3
Amiodaronum
Aratac
Leosigua
Riociguat (250 mg)
625115-55-1
615115-55-1
C20H19FN8O2
API
Copyright 2019 ? ChemicalBook. All rights reserved
Product Name*
CAS.No
Inquiry Amount*
Port*
Inquiry Description*
+Add Attachment(File Format: Jpg, Gif, Png, PDF,Zip,Txt,doc or xls Max Size: 3MB)