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N-Tosyl-5-bromo-4,7-diazaindole

N-Tosyl-5-bromo-4,7-diazaindole Struktur
1201186-54-0
CAS-Nr.
1201186-54-0
Englisch Name:
N-Tosyl-5-bromo-4,7-diazaindole
Synonyma:
2-BroMo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine;5H-Pyrrolo[2,3-b]pyrazine, 2-bromo-5-[(4-methylphenyl)sulfonyl]-;Upatinib Impurity 2;Upatinib Impurity 45;Upadacitinib Impurity 2;Upadacitinib Impurity 45;N-Tosyl-5-bromo-4,7-diazaindole;Glycerol(Glycerophosphoric acid);3-Bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine;2-BROMO-5-(P-TOLYLSULFONYL)-5H-PYRROLO[2,3-B]PYRAZINE
CBNumber:
CB62470216
Summenformel:
C13H10BrN3O2S
Molgewicht:
352.21
MOL-Datei:
1201186-54-0.mol

N-Tosyl-5-bromo-4,7-diazaindole Eigenschaften

Siedepunkt:
499.6±55.0 °C(Predicted)
Dichte
1.68±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-2.22±0.30(Predicted)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

N-Tosyl-5-bromo-4,7-diazaindole Chemische Eigenschaften,Einsatz,Produktion Methoden

synthetische

A solution of anhydrous DMF (272 mL) dissolved with 2-bromo-5H-pyrrolo[2,3-b]pyrazine (78.0 g, 394 mmol) was configured. The temperature is maintained at 0-5 °C (within which the subsequent reaction has been maintained), and the solution was droppedly added to the sodium (12.8 g, 532 mmol) anhydrous DMF (543 mL) suspension in the stirred state within 60 minutes. The solution turned brown and the reaction solution was stirred for about 30 min. Then, within 60 minutes, anhydrous DMF (272 mL) dissolved with p-toluenesulfonyl chloride (94.0 g, 492 mmol) was added. After stirring the mixed solution for about 1 h, it was heated to ambient temperature and stirred for about 18 h. Slowly pour the reaction mixture into ice water (6 L) and added 2.5 N NaOH in water (50.0 mL, 125 mmol). Filter the sediment to collect and stirred 3 times with cold water (200 mL). Finally, the collected products were filtered and dried to a constant weight in a vacuum oven at about 55 °C to obtain N-Tosyl-5-bromo-4,7-diazaindole (134.6 g, 97%).
N-Tosyl-5-bromo-4,7-diazaindole

Einzelnachweise

[1] Yael Ross, Marina Magrey, Use of upadacitinib in the treatment of psoriatic arthritis, Immunotherapy, 2021, 13.
[2] Lina Serhal, Christopher J Edwards, Upadacitinib for the treatment of rheumatoid arthritis, Expert Review of Clinical Immunology, 2018, 15,13-25.
[3] Eleni Kotsiliti, Upadacitinib therapy for Crohn’s disease, Nature Reviews Gastroenterology & Hepatology, 2023, 20, 483.

N-Tosyl-5-bromo-4,7-diazaindole Upstream-Materialien And Downstream Produkte

Upstream-Materialien

5-Bromo-4,7-diazaindole 5-[(4-methylphenyl)sulfonyl]-5H-Pyrrolo[2,3-b]pyrazin-2-amine 5-bromo-3-((trimethylsilyl)ethynyl)pyrazin-2-amine Tosylchlorid

Downstream Produkte

tert-butyl 5-tosyl-5H-pyrrolo[2,3-b]pyrazin-2-ylcarbamate

N-Tosyl-5-bromo-4,7-diazaindole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 184)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Golden Pharma Co., Limited
+undefined18958062155
 sales@zjgoldpharm.com China 5899 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410
 sales@ichemie.com China 1015 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 20259 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32965 60
Anhui Dexinjia Biopharm Co., Ltd 		+86-531-82371986 +86-15064117275
 sales01@jndxj.com China 291 58
Shanghai Worldyang Chemical Co.,Ltd. 		+86-021-56795779 +8613651600618
 sales@worldyachem.com China 1227 58
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
Shanghai Jinghao Pharmaceutical Co.,Ltd 		+86-21-68900963
sales@jinghaopharma.com CHINA 153 58
Shanghai Yingrui Biopharma Co.,Ltd 		21-33585366
export01@shyrchem.com CHINA 1319 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29809 58
  • N-Tosyl-5-bromo-4,7-diazaindole
  • 2-Bromo-5-[(4-methylphenyl)sulfonyl]-5H-pyrrolo[2,3-b]pyrazine
  • 2-BROMO-5-(P-TOLYLSULFONYL)-5H-PYRROLO[2,3-B]PYRAZINE
  • 2-bromo-5-(4-methylphenyl)sulfonylpyrrolo[2,3-b]pyrazine
  • 2-bromo-5-(4-methylbenzenesulfonyl)-5H-pyrrolo[2,3-b]pyrazine
  • Upadacitinib Impurity 2
  • 2-BroMo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine
  • 5H-Pyrrolo[2,3-b]pyrazine, 2-bromo-5-[(4-methylphenyl)sulfonyl]-
  • Glycerol(Glycerophosphoric acid)
  • 3-Bromo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine
  • 2-BroMo-5-tosyl-5H-pyrrolo[2,3-b]pyrazine,N-Tosyl-5-bromo-4,7-diazaindole
  • Upadacitinib Impurity 45
  • Upatinib Impurity 45
  • Upatinib Impurity 2
  • 1201186-54-0
  • Azaindoles
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