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tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Struktur
571188-59-5
CAS-Nr.
571188-59-5
Englisch Name:
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
Synonyma:
1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE;OTAVA-BB;4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester;OTAVA-BB 1207229;1-Boc-4-(6-amino-3-pyridyl)piperazine;tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate;POB02;Ribociclib-2;PALBOCICLIB4;Palbociclib-11
CBNumber:
CB62464781
Summenformel:
C14H22N4O2
Molgewicht:
278.35
MOL-Datei:
571188-59-5.mol

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Eigenschaften

Schmelzpunkt:
130-132℃
Siedepunkt:
454.1±45.0 °C(Predicted)
Dichte
1.182
Dampfdruck
0-0Pa at 20-25℃
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
L?slichkeit
DMSO (Slightly), Methanol (Very Slightly)
Aggregatzustand
Solid
pka
7.36±0.26(Predicted)
Farbe
Dark Yellow
Sensitive 
Air Sensitive
InChI
InChI=1S/C14H22N4O2/c1-14(2,3)20-13(19)18-8-6-17(7-9-18)11-4-5-12(15)16-10-11/h4-5,10H,6-9H2,1-3H3,(H2,15,16)
InChIKey
RMULRXHUNOVPEI-UHFFFAOYSA-N
SMILES
N1(C(OC(C)(C)C)=O)CCN(C2=CC=C(N)N=C2)CC1
LogP
1.6-1.8 at 35℃ and pH7-9
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
HS Code  2933599590
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P304+P340 BEI EINATMEN: Die Person an die frische Luft bringen und für ungehinderte Atmung sorgen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P405 Unter Verschluss aufbewahren.

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is a pharmaceutical intermediate compound that can be used to synthesize the targeted cancer drug Ribociclib for the treatment of ER-positive and HER2-negative breast cancer.

Verwenden

4-(6-Amino-3-pyridyl)-1-Boc-piperazine (tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate) is used as an organic chemical synthesis intermediate.

synthetische

4- (6-Nitro-pyridin-3-yl)-piperazine-1 -carboxylic acid ie f-butyl ester and Pd/C in ethanol is stirred with an H2 balloon for 3 h. The product tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate is obtained through purification.
tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate 1-BOC-Piperazine 2-Amino-5-iodopyridine

Downstream Produkte

Pyrido[2,3-d]pyriMidine-6-carboxylic acid, 8-cyclopentyl-2-[[5-[4-[(1,1-diMethylethoxy)carbonyl]-1-piperazinyl]-2-pyridinyl]aMino]-7,8-dihydro-5-Methyl-7-oxo-, ethyl ester

tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 586)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou Qiwei Pharmatech Co.,Ltd
13282840061
 mw@qwpharmatech.com China 109 58
ChemExpress
+86-021-58950125 +86-021-58950125;
 info@chemexpress.com China 780 58
SHANDONG BOYUAN PHARMACEUTICAL CO., LTD.
+86-0531-69954981 +8615666777973
 dwyane.wang@boyuanpharm.com China 211 58
Finetech Industry Limited
+86-27-87465837 +8618971612321
 info@finetechnology-ind.com China 9639 58
Shanghai Joiny Pharmaceutical Co.,LTD 		+8613681955282
 gyd@joiny-pharma.com China 311 58
Henan Bao Enluo International TradeCo.，LTD 		+86-17331933971 +86-17331933971
 deasea125996@gmail.com China 2472 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410
 sales@ichemie.com China 1010 58
ShenZhen H&D Pharmaceutical Technology Co., LTD 		+8618627948422
 sale@hdimpurity.com China 3389 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29793 60
Beijing Cooperate Pharmaceutical Co.,Ltd 		010-60279497
sales01@cooperate-pharm.com CHINA 1803 55

571188-59-5()Verwandte Suche:

  • 1-Piperazinecarboxylic acid, 4-(6-aMino-3-pyridinyl)-, 1,1-diMethylethyl ester
  • tert-butyl 4-(6-aMinopyri
  • 4-(6-aMinopyridin-3-yl)piperazine-1-carboxylic
  • 4-(6-AMinopyridin-3-yl)-1-Boc-piperazine
  • tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate(For Palbociclib)
  • Palbociclib's intermediate
  • 4-(6-aMinopyridin-3-yl)p
  • t-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • 1-(3-Methyl-1-phenyl-1H-pyrazol-5-yl)- (acetate)
  • Palbociclib Intermediate
  • Ribociclib-2
  • tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate
  • Tert-Butyl 4-(6-Amino-3-Pyrimidin)Piperazine-1-Carboxylate
  • 4-(6-Amino-3-pyridyl)piperazine-1-carboxylic Acid tert-Butyl Ester
  • tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • PALBOCICLIB4
  • 2-Methyl-2-propanyl 4-(6-amino-3-pyridinyl)-1-piperazinecarboxylate
  • 6-(6-Aminopyridin-3-yl)piperazine, N1-BOC protected 98%
  • 1-Butyloxycarbonyl-4-(6-aminopyridin-3-yl)-piperazine
  • Palbociclib Impurity 68
  • Palbociclib-018
  • Palbociclib-11
  • Tert-buty 4-(6-amino-3-pyridyl)piperazine-1-carboxylate
  • POB02
  • OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine
  • tert-butyl 4-(6-aminoyridin-3-yl)pipera-zine-1-carboxylate
  • OTAVA-BB 1207229 tert-butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • 1-(tert-Butoxycarbonyl)-4-(6-aminopyridin-3-yl)piperazine
  • Palbociclib Intermediate 1, tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • OTAVA-BB 1207229/1-Boc-4-(6-aminopyridin-3-yl)piperazine(571188-59-5)
  • 4-(6-Amino-3-pyridyl)-1-Boc-piperazine
  • 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZIN
  • tert-Butyl 4-(6-Amino-3-pyridyl)piperazine-1-carboxylate >
  • 4-(6-aminopyridine-3-yl) piperazine-1-carboxylic tert-butyl ester
  • )piperazine-1-carboxyL
  • Ribociclib Related Compound 1
  • Tert-Butyl 4-(6-aminopyridin-3-piperazine-1-carboxylate
  • 4-(6- aminopyridine -3- yl) piperazine -1- tert-butyl carboxylate
  • ert-Butyl4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • 1-tert-Butoxycarbonyl-4-(6-amino-3-pyridyl)piperazine
  • 1-BOC-4-(6-AMINOPYRIDIN-3-YL)PIPERAZINE
  • OTAVA-BB 1207229
  • 4-(6-Aminopyridin-3-yl)piperazine-1-carboxylic acid tert-butyl ester
  • tert-butyl 4-(6-amino-3-pyridyl)piperazine-1-carboxylate
  • OTAVA-BB
  • 1-Boc-4-(6-amino-3-pyridyl)piperazine
  • 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate
  • Palbociclib side chain
  • 4- (6-aminopyridine-3-yl) piperazin-1-carboxylic acid tert-butyl ester
  • tert-Butyl-4-(6-aminopyridin-3-yl)piperazin-1-carboxylate
  • 571188-59-5
  • 571188-59-9
  • PD 0332991
  • Palbociclib
  • Anticancer
  • 571188-59-5
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