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7-Ethyl-10-hydroxycamptothecin

7-Ethyl-10-hydroxycamptothecin Struktur
130144-34-2
CAS-Nr.
130144-34-2
Englisch Name:
7-Ethyl-10-hydroxycamptothecin
Synonyma:
Camptothecin Impurity 21;7-Ethyl-10-hydroxycamptothecin;7-ETHYL-10-HYDROXYCAMPTOTHECIN;7-Ethyl-10-hydroxycamptothecin;(rac)-7-Ethyl-10-Hydroxy camptothecin;rac-4,11-Diethyl-9-hydroxycamptothecin;7-Ethyl-10-hydroxycamptothecin, racemic;(110714-48-2) 7-ethyl-10-hydroxycamptothecin;4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione;1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-
CBNumber:
CB62462141
Summenformel:
C22H20N2O5
Molgewicht:
392.41
MOL-Datei:
130144-34-2.mol

7-Ethyl-10-hydroxycamptothecin Eigenschaften

Siedepunkt:
810.3±65.0 °C(Predicted)
Dichte
1.51
pka
9.13±0.40(Predicted)
InChI
InChI=1S/C22H20N2O5/c1-3-12-13-7-11(25)5-6-17(13)23-19-14(12)9-24-18(19)8-16-15(20(24)26)10-29-21(27)22(16,28)4-2/h5-8,25,28H,3-4,9-10H2,1-2H3
InChIKey
FJHBVJOVLFPMQE-UHFFFAOYSA-N
SMILES
N1C2C(=CC(O)=CC=2)C(CC)=C2CN3C(C=12)=CC1C(CC)(O)C(=O)OCC=1C3=O

Sicherheit

7-Ethyl-10-hydroxycamptothecin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

7-Ethyl-10-hydroxycamptothecin: a potent topoisomerase I inhibitor
7-Ethyl-10-hydroxycamptothecin (SN-38), as a highly active topoisomerase (Topo) I inhibitor, is the active metabolic product of its prodrug irinotecan (CPT-11) commercially available as Camptosar. By combining with the Topo I-DNA covalent conjugate, the camptothecin analogue forms a ternary complex that blocks the repolymerization of the DNA strands during their replication, eventually leading to the cell apoptosis. Although SN-38 is about 100- to 1000-fold more potent than irinotecan, its clinical application is limited by its poor solubility and nonspecific toxicity[1].

7-Ethyl-10-hydroxycamptothecin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

7-Ethyl-10-hydroxycamptothecin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 84)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
SICHUAN XIELI PHARMACEUTICAL CO.,LTD.
+86-028-60118998 +8615830127659
 sales7@xielipharm.com China 24 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795
info@shochem.com CHINA 288 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427
 sales@conier.com China 49374 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29810 58
Wuhan ChemNorm Biotech Co.,Ltd. 		+86-27-8439 4403 18971486879
 sales@chemnorm.com CHINA 2935 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418684 +8618949823763
 sales@tnjchem.com China 25356 58
LUYUNJIA CHEMISTRY XIAMEN LIMITED 		+86-592-5360779 +86-13055435203
 China 5988 58
Xiamen Eagle Chemical Limited Corporation
yiyunchem@163.com China 5771 58
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
Abel@chembj.com CHINA 3191 55
Shanghai Hanhong Scientific Co.,Ltd. 021-54306202 13764082696
 info@hanhongsci.com China 42958 64
  • 7-Ethyl-10-hydroxycamptothecin
  • 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • 1H-Pyrano[3,4:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4,9-dihydroxy-
  • (110714-48-2) 7-ethyl-10-hydroxycamptothecin
  • (rac)-7-Ethyl-10-Hydroxy camptothecin
  • rac-4,11-Diethyl-9-hydroxycamptothecin
  • 7-Ethyl-10-hydroxycamptothecin, racemic
  • 4,11-Diethyl-4,9-dihydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
  • Camptothecin Impurity 21
  • 7-ETHYL-10-HYDROXYCAMPTOTHECIN
  • 7-Ethyl-10-hydroxycamptothecin
  • 130144-34-2
  • 86639-52-8
  • 86639-52-2
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