RILPIVIRINE HCL
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- CAS-Nr.
- 700361-47-3
- Englisch Name:
- RILPIVIRINE HCL
- Synonyma:
- Rilpivirine Hydrochloride;RILPIVIRINE HCL;Rilpivirine-d6 HCl;Rilpivirine HCl (TMC278;Ripivirine Hydrochloride;TMC 278. trade name Edurant
- CBNumber:
- CB62455679
- Summenformel:
- C22H19ClN6
- Molgewicht:
- 402.89
- MOL-Datei:
- 700361-47-3.mol
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RILPIVIRINE HCL Eigenschaften
- storage temp.
- Store at -20°C
- L?slichkeit
- DMSO:50.0(Max Conc. mg/mL);136.46(Max Conc. mM)
- Aggregatzustand
- Solid
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
RILPIVIRINE HCL Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Rilpivirine Hydrochloride was shown to be able to treat and or prevent immunodeficiency virus-1. It also has uses for anti-viral therapy
Definition
ChEBI: A hydrochloride obtained by reaction of rilpivirine with one equivalent of hydrochloric acid. Used for treatment of HIV.
Clinical Use
Rilpivirine hydrochloride (Edurant), a non-nucleoside reverse
transcriptase inhibitor (NNRTI), received its approval both from
the U.S. FDA and E.U. EMA in 2011 for the treatment of HIV-1 infection in treatment-na?ve adult patients. It was discovered and
developed by Janssen Pharmaceuticals and its subsidiary Tibotec
Pharmaceuticals. As a second generation NNRTI, rilpivirine hydrochloride
displayed higher potency and longer half-life with a 25 mg
once a day dose, compared to existing NNRTIs, such as the 200 mg
BID of efavirenze (Sustiva). In late 2011, the fixed-dose
combination products of rilpivirine hydrochloride with two
nucleoside reverse transcriptase inhibitor (RTIs) emtricitabine and tenofovir disoproxil fumarate, co-developed by Gilead Science
and Tibotec, were also approved both by the FDA and EMA under
brand names Complera® and Eviplera®, respectively.
RILPIVIRINE HCL Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
RILPIVIRINE HCL Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 79)Lieferanten
- RILPIVIRINE HCL
- Rilpivirine-d6 HCl
- Rilpivirine HCl (TMC278
- TMC 278. trade name Edurant
- Rilpivirine Hydrochloride
- Ripivirine Hydrochloride
- 700361-47-3
- C22H19ClN6
- 700361-47-3
