2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
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- CAS-Nr.
- 299442-43-6
- Englisch Name:
- 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
- Synonyma:
- NKY80;AKOS B003518;VITAS-BB TBB000019;SALOR-INT L203769-1EA;NKY 80, adenylyl cyclase 5 inhibitor;Adenylyl Cyclase Type V Inhibitor, NKY80;2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one;2-AMINO-7-(FURANYL)-7,8-DIHYDRO-5(6H)-QUINAZOLINONE;2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE;2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
- CBNumber:
- CB6144364
- Summenformel:
- C12H11N3O2
- Molgewicht:
- 229.23
- MOL-Datei:
- Mol file
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2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Eigenschaften
- Siedepunkt:
- 464.9±47.0 °C(Predicted)
- Dichte
- 1.360±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in DMSO or methanol
- Aggregatzustand
- powder
- pka
- 1.85±0.40(Predicted)
- Farbe
- off-white to light brown
- Sensitive
- Light Sensitive
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi,T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| WGK Germany |
3 |
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| HazardClass |
IRRITANT |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P330 |
Mund ausspülen. |
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2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
NKY 80 is an inhibitor of adenylyl cyclase (AC) and displays a greater affinity for AC5 over AC3 and AC2. Adenyl cyclase inhibitors can be easily modified by tumor targeting structures.
Allgemeine Beschreibung
A cell-permeable quinazolinone containing a non-nucleoside compound that acts as a potent, selective inhibitor of adenylyl cyclase (AC) type V isoform (IC
50 = 8.3 μM, 132 μM and 1.7 mM for type V, III and II, respectively) in the presence of G
sα GTPγS-Forskolin. Displays ~210-fold greater selectivity for type V over the type II isoform. The inhibition is non-competitive with respect to ATP and Forskolin. Regulates the AC catalytic activity in heart and lung tissues.
Biochem/physiol Actions
Cell permeable: yes
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 76)Lieferanten
- 2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
- Adenylyl Cyclase Type V Inhibitor, NKY80
- 2-AMINO-7-FURAN-2-YL-7,8-DIHYDRO-6H-QUINAZOLIN-5-ONE
- 2-AMINO-7-(FURANYL)-7,8-DIHYDRO-5(6H)-QUINAZOLINONE
- AKOS B003518
- SALOR-INT L203769-1EA
- NKY80
- VITAS-BB TBB000019
- 2-amino-7-(2-furyl)-7,8-dihydroquinazolin-5(6H)-one
- 5(6H)-Quinazolinone, 2-amino-7-(2-furanyl)-7,8-dihydro-
- Adenylyl Cyclase Type V Inhibitor, NKY80 - CAS 299442-43-6 - Calbiochem
- 2-Amino-7-(furan-2-yl)-7,8-dihydroquinazolin-5(6H)-one
- NKY 80, adenylyl cyclase 5 inhibitor
- 299442-43-6
