Ancarolol Chemische Eigenschaften,Einsatz,Produktion Methoden
Originator
Ancarolol,ZYF Pharm Chemical
Manufacturing Process
A mixture of 23 g of 2'-(2,3-epoxypropoxy)-furan-2-carboxylic acid anilide,
7.3 g of t-butylamine and 50 ml of isopropanol is boiled under reflux for 10
hours. On cooling, 2'-(2-hydroxy-3-t-butylaminopropoxy)-furan-2-carboxylic
acid anilide (ancarolol) crystallizes out from the solution. The
chromatographically pure base is obtained in the form of a white solid of
melting point 112°-113°C by recrystallization from ethyl acetate. The yield is
12 g. The colorless, crystalline base is dissolved in alcohol, alcoholic HCl is
added and the hydrochloride is induced to crystallize by adding ether
dropwise. After isolation, the salt is recrystallized again from ethanol. This
gives 10 g of the hydrochloride, melting point 189°-191°C.
Therapeutic Function
Beta-adrenergic blocker
Ancarolol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
