3-Bromo-4-hydroxypyridine
|
|
|
- CAS-Nr.
- 36953-41-0
- Englisch Name:
- 3-Bromo-4-hydroxypyridine
- Synonyma:
- 3-Bromopyridin-4-ol;3-BROMO-4-PYRIDINOL;4-Pyridinol, 3-bromo-;3-bromo-1H-pyridin-4-one;3-BROMO-4-HYDROXYPYRIDINE;4-HYDROXY-3-BROMOPYRIDINE;3-Bromo-4-hydroxypyridine,97%;3-BROMO-4-HYDROXYPYRIDINE 97%;Synthesis of 3-bromopyridin-4-ol;3-Bromo-4-hydroxypyridine ISO 9001：2015 REACH
- CBNumber:
- CB6110145
- Summenformel:
- C5H4BrNO
- Molgewicht:
- 174
- MOL-Datei:
- 36953-41-0.mol
|
3-Bromo-4-hydroxypyridine Eigenschaften
- Schmelzpunkt:
- 225-230℃
- Siedepunkt:
- 338.2±22.0 °C(Predicted)
- Dichte
- 1.788±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Room Temperature
- Aggregatzustand
- powder
- pka
- 3.71±0.18(Predicted)
- Farbe
- light yellow
- CAS Datenbank
- 36953-41-0(CAS DataBase Reference)
3-Bromo-4-hydroxypyridine Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
3-Bromo-4-hydroxypyridine is a pyrrole that can be used in cancer treatment. It inhibits the growth of cancer cells by binding to MKN-45 on the cell surface, thereby preventing it from binding to other proteins and triggering cell proliferation.
Synthese
3-Bromo-4-hydroxypyridine is synthesized from 3-bromo-5 hydroxypyridine by reacting it with ammonia or methylamine.
Concentrated sulfuric acid (85.0mL) and the 3-bromo-4-aminopyridine (113.0g, 0.65mol) were added successively to the distilled water (550.0mL) at 0°C, and then NaNO2 (63.1g, 0.91mol) aqueous solution (130.0mL) was added drop-wise to maintain the temperature between 0 and 5°C. After stirring at r. t. for 1h, the reaction mixture was heated at 95°C for a further 0.5h. Upon cooling to below 0°C, the mixture was alkalized to pH 6 with saturated sodium hydroxide solution, washed with ethyl acetate (200mL×3) and brine (200mL), dried over anhydrous Na2SO4, filtered and concentrated to yield 3-Bromo-4-hydroxypyridine as a yellow solid (75.1g, 66.2percent).
3-Bromo-4-hydroxypyridine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-Bromo-4-hydroxypyridine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 178)Lieferanten
36953-41-0()Verwandte Suche:
- 3-BROMO-4-HYDROXYPYRIDINE
- 3-BROMO-4-PYRIDINOL
- 4-HYDROXY-3-BROMOPYRIDINE
- 3-BROMO-4-HYDROXYPYRIDINE 97%
- Synthesis of 3-bromopyridin-4-ol
- 4-Pyridinol, 3-bromo-
- 3-Bromo-4-hydroxypyridine,97%
- 3-Bromo-4-hydroxypyridine ISO 9001：2015 REACH
- 3-bromo-1H-pyridin-4-one
- 3-Bromopyridin-4-ol
- 36953-41-0
- 133466-43-8
- Pyridine
- Pyridines
