2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
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- CAS-Nr.
- 302964-24-5
- Englisch Name:
- 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
- Synonyma:
- EOS-61515;2-Amino-N-(2-chL;Dasatinib Int N-2;The dimer impurity;Dasatinib IMpurity 2;Dasatinib Impurity L;Dasatinib Impurity 27;dasatinib interMediate;Dasatinib EP Impurity-A;2-AMino-N-(2-chloro-6-Meth
- CBNumber:
- CB61090897
- Summenformel:
- C11H10ClN3OS
- Molgewicht:
- 267.73
- MOL-Datei:
- 302964-24-5.mol
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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Eigenschaften
- Schmelzpunkt:
- 208.0 to 212.0 °C
- Siedepunkt:
- 362.0±37.0 °C(Predicted)
- Dichte
- 1.474±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- L?slichkeit
- DMSO (Slightly), Methanol (Sparingly)
- Aggregatzustand
- powder to crystal
- pka
- 11.09±0.70(Predicted)
- Farbe
- White to Light yellow
- InChI
- InChI=1S/C11H10ClN3OS/c1-6-3-2-4-7(12)9(6)15-10(16)8-5-14-11(13)17-8/h2-5H,1H3,(H2,13,14)(H,15,16)
- InChIKey
- VVOXTERFTAJMAA-UHFFFAOYSA-N
- SMILES
- S1C(C(NC2=C(C)C=CC=C2Cl)=O)=CN=C1N
- CAS Datenbank
- 302964-24-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P330 |
Mund ausspülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Synthese
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide is synthesised using Tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-YL)carbamate as a raw material by chemical reaction. The specific synthesis steps are as follows:
To the stirred solution of trifluoroacetic acid (TFA) (250.0 mL) added tert-butyl (5-((2-chloro-6-methylphenyl)carbamoyl)thiazol-2-yl)carbamate 23 (25.0 g, 0.07 mol) and stirred for 2h at 25-30°C. Reaction completion was confirmed by TLC, distilled the TFA and the residue was diluted with ethyl acetate (EtOAc),(250.0 mL). Ethyl acetate layer was washed with saturated NaHCO3 solution (2 X 25.0 mL), water, followed bysaturated NaCl solution (125.0 mL). Ethyl acetate layer was dried over Na2SO4 and concentrated. The residual mass on treatment with methyl tert-butyl ether (250.0) gave 9 (16.2 g, 89percent) [11].IR (KBr, cm-1): 3382.4, 3284.85 (N-H), 1627.02 (C=O), 1644; 1H NMR spectrum (400 MHz, DMSO-d6), δ, ppm(J, Hz): 9.63 (s, 1H, thiazole-H), 7.86 (s, 1H), 7.60 (s, 2H, -NH2), 7.38 (dd, 1H, J =7.5, 4.02, Ar-H), 7.20-7.22 (m,2H, J =7.5, Ar-H), 2.20 (s, 3H, Ar-CH3); 13C NMR spectrum (100 MHz, DMSO-d6), δ, ppm: 172.2, 159.6, 143.2,138.9, 133.7, 132.5, 129.0, 128.0, 127.0, 120.7 and 18.3; MS (ESI) m/z 268.0 [M + H] + [11].
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 431)Lieferanten
302964-24-5()Verwandte Suche:
- Dasatinib IMpurity 2
- 2-AMino-N-(2-chloro-6-Methylphenyl)thiazole-5-carboxiMide)
- 2-Amino-5-[(2-chloro-6-methylphenyl)carbamoyl]-1,3-thiazole, 2-Amino-5-[(6-chloro-o-tolyl)carbamoyl]-1,3-thiazole
- 5-ThiazolecarboxaMide,2-aMino-N-(2-chloro-6-Methylphenyl)
- Dasatinib Int N-2
- 2-AMino-N-(2-chloro-6-Meth
- 2-AMino-N-(2-chloro-6-Methylphenyl)-5-thiazolecarboxaMide
- 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide
- 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide(Intermediate of Dasatinib)
- 2-AMINO-N-(2-CHLORO-6-METHYLPHENYL)THIAZOLE-5-CARBOXAMIDE
- 2-AMino-N-(2-chloro-6-Methylphenyl)thiazole-5-carb
- 2-aMino-N-(2-chloro-6-Methylphenyl)-1,3-thiazole-5-carboxaMide
- dasatinib interMediate
- 2-Amino-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide 98%
- EOS-61515
- The dimer impurity
- Dasatinib Impurity 27
- 2-Amino-N-(2-chloro-6-methylphenyl)thiazole-5-carboxamide >
- 2-Amino-N-(2-chL
- Dasatinib Aminothiazole Impurity
- 2- Amino-N - (2-chloro-6-methylphenyl) thiazole-5-carboxylamide
- Dasatinib Impurity L
- 2-Amino-N - (2-chloro-6-methylphenyl) thiazole-5-formamide
- 2-Amino-N-(2-chloro-6-methylphenyl)thiazol-5-carboxamide
- 2-Amino-N - (2-chloro-6-methylphenyl) -5-thiazolamide
- Dasatinib EP Impurity-A
- 302964-24-5
- 392064-08-5
- Dasatinib
- API intermediates
