SB269970 HCl Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The transduction of neurobehavioral effects by serotonin (5-hydroxy tryptamine; 5-HT) is mediated by at least seven major 5-HT receptor subtypes. SB-269970 is a potent 5-HT_7A antagonist (pK_i = 8.9) that demonstrates >50-fold binding selectivity over 5-HT_5A and >250-fold selectivity over 5-HT₁, 5-HT₂, 5-HT₄, 5-HT₆, adrenergic α₁, dopamine D₂, and dopamine D₃ receptors. It is also reported to block adrenergic α₂ receptors in guinea pig vas deferens. SB-269970 has been used to target the 5-HT₇ receptor in the study of schizophrenia-like cognitive deficits.

Verwenden

SB 269970A is a selective 5-HT7 receptor antagonist.

Allgemeine Beschreibung

A selective 5-HT₇ receptor antagonist. Extremely potent in vivo and in vitro. Chronic or acute (even single dose) administration of SB269970 induces functional desensitization of the 5-HT₇ receptor system, which precedes changes in the receptor density. This mechanism may be responsible for the rapid antidepressant-like effect of the 5-HT₇ antagonist in animal models. SB-269970 is an analogue of SB-258719 and has been shown to have at least 100 fold selectivity versus all other 5-HT receptor subtypes except the human 5-HT_5A receptor (pKi values are 8.9, 7.2 and 6.0 for 5-HT_7A, 5-HT_5A and 5-HT_1B).

SB269970 HCl Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SB269970 HCl Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22784	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
Sichuan Biosynce Pharmatech Co., Ltd.	+8619950309693	diane@biosynce.com	China	4871	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7552	61
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-400-6206333 18521732826	market@aladdin-e.com	China	25003	65
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
Suzhou yacoo science co.,Ltd	0512-87182056 18013166090	lingling.qi@yacoo.com.cn	China	7295	60

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• SB-269970A
• (R)-3-((2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidin-1-yl)sulfonyl)phenol hydrochloride
• (r)-3-[2-[2-(4-methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride
• SB 269970A, (R)-3-[2-[2-(4-Methylpiperidin-1-yl)ethyl]pyrrolidine-1-sulfonyl]phenol hydrochloride
• (2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidine monohydrochloride
• Phenol, 3-[[(2R)-2-[2-(4-methyl-1-piperidinyl)ethyl]-1-pyrrolidinyl]sulfonyl]-, hydrochloride (1:1)
• SB269970 hydrochloride, >=98%
• SB269970 HClSB269970 HCl
• SB269970 HCl USP/EP/BP
• SB269970 HCl (SB-269970A)
• SB-269970A|||SB269970 HCl
• 261901-57-9
• C18H28N2O3SHCl
• Inhibitors