GW 3965 HYDROCHLORIDE
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- CAS-Nr.
- 405911-17-3
- Englisch Name:
- GW 3965 HYDROCHLORIDE
- Synonyma:
- CS-742;GW3965 HCl;GW3965 HCl Salt;W 3965 HYDROCHLORIDE;GW3965 hydrochloride, >=98%;GW-3965 hydrochloride GW3965;GW 3965 HYDROCHLORIDE; GW-3965 HYDROCHLORIDE;;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…;2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylet...;3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenylacetic Acid Hydrochloride
- CBNumber:
- CB5972490
- Summenformel:
- C33H31ClF3NO3.HCl
- Molgewicht:
- 0
- MOL-Datei:
- 405911-17-3.mol
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GW 3965 HYDROCHLORIDE Eigenschaften
- storage temp.
- Store at -20°C
- L?slichkeit
- DMSO: ≥20mg/mL
- Aggregatzustand
- powder
- Farbe
- white
- InChIKey
- NMPUWJFHNOUNQU-UHFFFAOYSA-N
GW 3965 HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ.
Biochem/physiol Actions
GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively.
GW 3965 HYDROCHLORIDE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GW 3965 HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 121)Lieferanten
405911-17-3()Verwandte Suche:
- 3-[3-[n-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride
- 3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…
- GW3965 HCl
- 2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid hydrochloride
- GW3965 hydrochloride, >=98%
- Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride
- GW3965 HCl Salt
- 3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride
- CS-742
- GW 3965 HYDROCHLORIDE; GW-3965 HYDROCHLORIDE;
- 3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenylacetic Acid Hydrochloride
- 2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylet...
- GW-3965 hydrochloride GW3965
- Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride (1:1)
- 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-Benzeneacetic acid hydrochloride (1:1)
- W 3965 HYDROCHLORIDE
- 405911-17-3
- C33H31F3ClNO3HCl
- Inhibitors