ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40)
|
|
|
- CAS-Nr.
- Englisch Name:
- ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40)
- Synonyma:
- ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40);ANTI-RAT TYROSINE HYDROXYLASE, PHOSPHOSER 40;ANTI-TYROSINE HYDROXYLASE (PSER40) RABBIT PAB;ANTI-TYROSINE HYDROXYLASE, RAT, PHOSPHO-SPECIFIC (SER40), RAT;Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit
- CBNumber:
- CB5690172
- Summenformel:
- Molgewicht:
- 0
- MOL-Datei:
- Mol file
|
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Eigenschaften
- storage temp.
- −20°C
- Aggregatzustand
- aqueous glycerol solution
- Biologische Quelle
- rabbit
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Chemische Eigenschaften,Einsatz,Produktion Methoden
Allgemeine Beschreibung
Tyrosine Hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15.5, close to the insulin (INS) and Harvey-ras-1 (HRAS) genes. The N-terminal end of the protein plays a vital role in maintaining intracellular stability of the enzyme. tyrosine hydroxylase is expressed in various tissues such as brain, adrenal medulla and sympathetically innervated tissues. The enzyme is characterized with a regulatory domain (R), a catalytic domain (C) at N-terminal end, and a coiled-coil domain at the C-terminal end.
Biochem/physiol Actions
Tyrosine Hydroxylase (TH) specifically catalyzes the hydroxylation of the amino acid L-tyrosine to 3, 4-dihydroxy-L-phenylalanine (L-DOPA). TH is a rate-limiting enzyme involved in the synthesis of catecholamine, involved in several brain functions, such as attention, memory, cognition, and emotion. Phosphorylation of the N-terminal portion of tyrosine hydroxylase controls the degradation of this enzyme by the ubiquitin-proteasome pathway. Alteration in the expression of the gene results in the pathogenesis of Parkinson′s disease (PD). Point mutation in the gene coding for TH leads to Segawa′s syndrome.
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 4)Lieferanten
- ANTI-TYROSINE HYDROXYLASE (PSER40) RABBIT PAB
- ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40)
- ANTI-RAT TYROSINE HYDROXYLASE, PHOSPHOSER 40
- Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit
- ANTI-TYROSINE HYDROXYLASE, RAT, PHOSPHO-SPECIFIC (SER40), RAT
