O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI
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- CAS-Nr.
- 132489-69-1
- Englisch Name:
- O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI
- Synonyma:
- (Z)-Pugnac;(Z)-PUGNAc min. 99%;PUGNAc extrapure, 95%;O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI;PugNAc, hexosaminidase A and B inhibitor;acetamidodeoxy-D-glucopyranosylideneamino phenylcarbamate;n-acetylglucosaminono-1,5-lactoneo-(phenylcarbamoyl)oxime;O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate;O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate;(Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
- CBNumber:
- CB5503122
- Summenformel:
- C15H19N3O7
- Molgewicht:
- 353.33
- MOL-Datei:
- 132489-69-1.mol
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O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Eigenschaften
- Schmelzpunkt:
- 172-175°C
- Dichte
- 1.53
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (up to 35 mg/ml)
- Aggregatzustand
- solid
- pka
- 11.85±0.70(Predicted)
- Farbe
- White
- BRN
- 4274031
- Stabilit?t:
- Moisture and Temperature Sensitive
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
29329990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
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O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Proteins can be modified post-translationally by the addition of
O-linked N-acetylglucosamine (
O-GlcNAc). Nuclear cytoplasmic
O-GlcNAcase and acetyltransferase (NCOAT) is a β-N-acetylglucosaminidase that removes GlcNAc from
O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (K
i = 40-110 nM). It also less potently inhibits other hexosaminidases and exochitinases. (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both
in vitro and in cells.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
An inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B
Biologische Aktivit?t
O -GlcNAc- β - N -acetylglucosaminidase ( O -GlcNAcase) and β -hexosaminidase inhibitor (K i values are 46 and 36 nM respectively) that increases O -GlcNAc levels ~ 2-fold in HT29 cells. Z -linked isomer is more potent than the E isomer.
O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 103)Lieferanten
132489-69-1()Verwandte Suche:
- (Z)-Pugnac
- O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
- O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate ,97%
- (Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
- (Z)-PUGNAc min. 99%
- O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI
- 2-(AcetylaMino)-2-deoxy-N-[[(phenylaMino)carbonyl]oxy]-D-gluconiMidic Acid δ-Lactone
- (1Z)-2-(Acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-D-gluconimidic acid delta-lactone
- n-acetylglucosaminono-1,5-lactoneo-(phenylcarbamoyl)oxime
- acetamidodeoxy-D-glucopyranosylideneamino phenylcarbamate
- O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate
- (5R,6R,7S,8R,Z)-6,7-Dihydroxy-8-(hydroxymethyl)-2,3-dioxo-N-((phenylcarbamoyl)oxy)-1,4-oxazocane-5-carbimidic acid
- D-Gluconimidic acid, 2-(acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-, δ-lactone, (1Z)-
- PUGNAc extrapure, 95%
- N-((3R,4R,5S,6R,Z)-4,5-Dihydroxy-6-(hydroxymethyl)-2-(((phenylcarbamoyl)oxy)imino)tetrahydro-2H-pyran-3-yl)acetamide
- (2Z,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-ylidene]amino N-phenylcarbamate
- PugNAc, hexosaminidase A and B inhibitor
- 132489-69-1
- Carbohydrates & Derivatives
- Glycosidase Inhibitors
- Inhibitors
