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O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Struktur
132489-69-1
CAS-Nr.
132489-69-1
Englisch Name:
O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI
Synonyma:
(Z)-Pugnac;(Z)-PUGNAc min. 99%;PUGNAc extrapure, 95%;O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI;acetamidodeoxy-D-glucopyranosylideneamino phenylcarbamate;n-acetylglucosaminono-1,5-lactoneo-(phenylcarbamoyl)oxime;O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate;O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate;(Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate;O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate ,97%
CBNumber:
CB5503122
Summenformel:
C15H19N3O7
Molgewicht:
353.33
MOL-Datei:
132489-69-1.mol

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Eigenschaften

Schmelzpunkt:
172-175°C
Dichte
1.53
storage temp. 
-20°C
L?slichkeit
Soluble in DMSO (up to 35 mg/ml)
Aggregatzustand
solid
pka
11.85±0.70(Predicted)
Farbe
White
BRN 
4274031
Stabilit?t:
Moisture and Temperature Sensitive
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
HS Code  29329990
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Proteins can be modified post-translationally by the addition of O-linked N-acetylglucosamine (O-GlcNAc). Nuclear cytoplasmic O-GlcNAcase and acetyltransferase (NCOAT) is a β-N-acetylglucosaminidase that removes GlcNAc from O-glycosylated proteins. PUGNAc is a (phenylcarbamoyl)oxime analog of GlcNAc that reversibly inhibits NCOAT (Ki = 40-110 nM). It also less potently inhibits other hexosaminidases and exochitinases. (Z)-PUGNAc is a stereoisomer of PUGNAc that is a more potent inhibitor of NCOAT than the (E) isomer, both in vitro and in cells.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

An inhibitor of O-GlcNAcase, hexosaminidase A, and hexosaminidase B

Biologische Aktivit?t

O -GlcNAc- β - N -acetylglucosaminidase ( O -GlcNAcase) and β -hexosaminidase inhibitor (K i values are 46 and 36 nM respectively) that increases O -GlcNAc levels ~ 2-fold in HT29 cells. Z -linked isomer is more potent than the E isomer.

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Upstream-Materialien And Downstream Produkte

Upstream-Materialien

O-(2-ACETAMIDO-3,4,6-TRI-O-ACETYL-D-GLUCOPYRANOSYLIDENE)AMINO N-PHENYL CARBAMATE 2-ACETAMIDO-2-DEOXY-D-GLUCONHYDROXIMO-1,5-LACTONE 1-N,3,4,6-TETRAACETATE 2-ACETAMIDO-3,4,6-TRI-O-ACETYL-2-DEOXY-D-GLUCOHYDROXIMO-1,5-LACTONE

Downstream Produkte

O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 104)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32820 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29886 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32002 58
ANHUI WITOP BIOTECH CO., LTD 		+8615255079626
 eric@witopchemical.com China 23541 58
Finetech Industry Limited 		+86-27-87465837 +8618971612321
 info@finetechnology-ind.com China 9640 58
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850
info@fortunachem.com China 5986 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152
 Mandy@hangyubiotech.com China 10986 58

132489-69-1()Verwandte Suche:

  • (Z)-Pugnac
  • O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino-Z-N-phenylcarbamate
  • O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenyl carbamate ,97%
  • (Z)-O-(2-Acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate
  • (Z)-PUGNAc min. 99%
  • O-[2-ACETAMIDO-2-DEOXY-D-GLUCOPYRANOSYLI
  • 2-(AcetylaMino)-2-deoxy-N-[[(phenylaMino)carbonyl]oxy]-D-gluconiMidic Acid δ-Lactone
  • (1Z)-2-(Acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-D-gluconimidic acid delta-lactone
  • n-acetylglucosaminono-1,5-lactoneo-(phenylcarbamoyl)oxime
  • acetamidodeoxy-D-glucopyranosylideneamino phenylcarbamate
  • O-(2-Acetamido-2-deoxy-D-glucopyranosylidenamino) N-phenylcarbamate
  • (5R,6R,7S,8R,Z)-6,7-Dihydroxy-8-(hydroxymethyl)-2,3-dioxo-N-((phenylcarbamoyl)oxy)-1,4-oxazocane-5-carbimidic acid
  • D-Gluconimidic acid, 2-(acetylamino)-2-deoxy-N-[[(phenylamino)carbonyl]oxy]-, δ-lactone, (1Z)-
  • PUGNAc extrapure, 95%
  • N-((3R,4R,5S,6R,Z)-4,5-Dihydroxy-6-(hydroxymethyl)-2-(((phenylcarbamoyl)oxy)imino)tetrahydro-2H-pyran-3-yl)acetamide
  • (2Z,3R,4R,5S,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-ylidene]amino N-phenylcarbamate
  • 132489-69-1
  • Carbohydrates & Derivatives
  • Glycosidase Inhibitors
  • Inhibitors
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