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Fludrocortison-21-acetat

Fludrocortisone acetate Struktur
514-36-3
CAS-Nr.
514-36-3
Bezeichnung:
Fludrocortison-21-acetat
Englisch Name:
Fludrocortisone acetate
Synonyma:
9α;U 4845;NSC 15186;cortineff;scherofluron;alfloroneacetate;Fluorocortisol acetate;FLUDROCORTISONE ACETATE;9-FLUOROCORTISOL ACETATE;9α-Fluorcortisol acetate
CBNumber:
CB5442481
Summenformel:
C23H31FO6
Molgewicht:
422.49
MOL-Datei:
514-36-3.mol

Fludrocortison-21-acetat Eigenschaften

Schmelzpunkt:
233-234°C
Siedepunkt:
575.1±50.0 °C(Predicted)
alpha 
D23 +123° (c = 0.64 in chloroform)
Dichte
1.0953 (rough estimate)
Brechungsindex
1.5980 (estimate)
storage temp. 
2-8°C
L?slichkeit
Practically insoluble in water, sparingly soluble in anhydrous ethanol.
pka
12.06±0.70(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
Wasserl?slichkeit
54mg/L(25 ºC)
InChIKey
UUHYILPJUKGJDI-XYNXPQAZSA-N
SMILES
F[C@]12[C@H](C[C@@]3([C@@](O)(C(=O)COC(=O)C)CC[C@@]3([H])[C@]1([H])CCC1=CC(=O)CC[C@]21C)C)O |&1:1,2,4,5,16,18,28,r|
CAS Datenbank
514-36-3(CAS DataBase Reference)
EPA chemische Informationen
Fluorocortisone acetate (514-36-3)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 63
S-S?tze: 22-26-36
WGK Germany  3
RTECS-Nr. TU5050000
HS Code  2937220000
Toxizit?t LD50 oral in rat: > 1gm/kg
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

Fludrocortison-21-acetat Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Fludrocortisone acetate is the acetate form of the synthetic corticosteroid fludrocortisone, which is a mineralocorticoid receptor agonist. Fludrocortisone acetate (0.1-5 μg/animal) promotes sodium retention in rats in a dose-dependent manner with 37% of sodium excreted compared with control when used at a dose of 5 μg/animal. Formulations containing fludrocortisone acetate have been used in the treatment of Addison’s disease.

Chemische Eigenschaften

Crystalline Solid

Definition

ChEBI: An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid acti ns are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia.

Allgemeine Beschreibung

Fludrocortisone acetate,21-acetyloxy-9-fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione, 9α-fluorohydrocortisone (Florinef Acetate), isused only for the treatment of Addison disease and for inhibitionof endogenous adrenocortical secretions. It has up to about 800 times the MC activity of hydrocortisone and about 11 times the GC activity. Its potent activity stimulated the synthesis and study of the many fluorinated steroids. Although its great salt-retaining activity limits its use to Addison disease, it has sufficient GC activity that in some cases of the disease, additional GCs need not be prescribed.

Fludrocortison-21-acetat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Fludrocortison-21-acetat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 225)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Nanjing Shizhou Biotechnology Co., Ltd
+86-15850508050 +86-15850508050
sean.lv@synzest.com China 323 58
Hangzhou ICH Biofarm Co., Ltd
+86-0571-28186870; +undefined8613073685410
sales@ichemie.com China 1001 58
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Longyan Tianhua Biological Technology Co., Ltd
0086 18039857276 18039857276
CHINA 2783 58

514-36-3(Fludrocortison-21-acetat)Verwandte Suche:


  • 17-dihydroxy-20-dion(11-beta)-pregn-4-ene-21-(acetyloxy)-9-fluoro-11
  • 20-dione,9-fluoro-11-beta,17,21-trihydroxy-pregn-4-ene-21-acetate
  • 9-alpha-fluorohydrocortisone-21-acetate
  • 9-alpha-fluorohydrocortisoneacetate
  • 9-fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione21-acetate
  • 9-fluoro-17-hydroxy-corticosteron21-acetate
  • FLUDROCORTISONEACETATE,MICRONIZED,USP
  • 9α-Fluoro-11β,17α,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
  • 9α-Fluorocortisol 21-acetate
  • 9α-Fluorohydrocortisone 21-acetate
  • Corticosterone, 9-fluoro-17-hydroxy-, 21-acetate (6CI)
  • Fluorocortisol acetate
  • Fluorohydrocortisone acetate
  • NSC 15186
  • Pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β)-
  • Pregn-4-ene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-, 21-acetate (7CI, 8CI)
  • U 4845
  • (11)-21-(Acetyloxy)-9-fluoro-11,17-dihydroxypregn-4-ene-3,20-dione
  • 9a-Fluorocortisol 21-acetate
  • Fludrocortisone acetate Solution, 100ppm
  • Fludrocortisone Acetate (200 mg)
  • Fludrocortisone 21- acetate solution,100ppm
  • 21-(Acetyloxy)-9-fluoro-11β,17-dihydroxypregn-4-ene-3,20-dione
  • Fludrocortisone Acetate (250 mg)
  • Fludrocortisone Acetate, Micronized
  • 9-Fluorocortisol acetate, 9-Fluorohydrocortisone acetate, 9α-Fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione acetate
  • Fludrocortisone Acetate Solution
  • alfloroneacetate
  • cortineff
  • fludrocortisone21-acetate
  • scherofluron
  • FLUDROCORTISONE ACETATE
  • 9-FLUOROCORTISOL ACETATE
  • 9-FLUOROHYDROCORTISONE ACETATE
  • 9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIHYDROXY-4-PREGNENE-3,20-DIONE ACETATE
  • 4-PREGNENE-9ALPHA-FLUORO-11BETA,17ALPHA,21-TRIOL-3,20-DIONE ACETATE
  • 4-PREGNEN-9-ALPHA-FLUORO-11-BETA, 17,21-TRIOL-3,20-DIONE ACETATE
  • [2-[(9s)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-17-yl]-2-oxo-ethyl] acetate
  • FLUDROCORTISONE ACETATE ASSAY STANDARD BP(CRM STANDARD)
  • 9α-fluoro-11β,17α,21-trihydroxy-4-pregnene-3,20-dione acetate
  • Fludrocortisone acetate CRS
  • Fludrocortisone Acetate RS
  • 9α-Fludrocortisone acetate
  • 9α-Fluorcortisol acetate
  • Fludrocortison-21-acetat
  • 2-((8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-2-oxoethyl acetate
  • Pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-,(11b)-
  • Fludrocortisone acetate USP/EP/BP
  • 9α-Fludrocortisone acetate
  • 9α-Fluorcortisol acetate
  • 9α-fluorocortisol acetate
  • Fludrocortisone Acetate (1273003)
  • 4-PREGNEN-9α-FLUORO-11β, 17, 21-TRIOL-3, 20-DIONE-21-ACETATE
  • Fludrocortisone acetate(9α-Fluorocortisone acetate)
  • 9α-Fluorocortisone acetate
  • C13707000 FludrocortisonEacetate
  • 514-36-3
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