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Acebutolol

Acebutolol Struktur
37517-30-9
CAS-Nr.
37517-30-9
Bezeichnung:
Acebutolol
Englisch Name:
Acebutolol
Synonyma:
Prent;Sectral;ACEBUTOLOL;Acebuprolol;Acebutololum;Acetobutolol;dl-Acebutolol;Acebutolo HCl;Acebutolol USP/EP/BP;AcebutololDiscontinued. See: A123800
CBNumber:
CB5393651
Summenformel:
C18H28N2O4
Molgewicht:
336.43
MOL-Datei:
37517-30-9.mol

Acebutolol Eigenschaften

Schmelzpunkt:
119-123°C
Siedepunkt:
472.9°C (rough estimate)
Dichte
1.1748 (rough estimate)
Brechungsindex
1.5700 (estimate)
storage temp. 
-20°C Freezer
L?slichkeit
DMF: 10 mg/mL,DMSO: 5 mg/mL,Ethanol: 5 mg/mL,PBS (pH 7.2): 0.3 mg/mL
Aggregatzustand
A solid
pka
pKa 9.40 (Uncertain)
Farbe
Crystals
Wasserl?slichkeit
259 mg/L
CAS Datenbank
37517-30-9(CAS DataBase Reference)
NIST chemische Informationen
Acebutolol(37517-30-9)
EPA chemische Informationen
Butanamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]- (37517-30-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Toxizit?t TDLo orl-wmn: 152 mg/kg:CVS,BPR JTCTDW 20,69,83
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H362 Kann S?uglinge über die Muttermilch sch?digen. Reproductive toxicity, effects on or via lactation Additional category P201, P260, P263, P264, P270,P308+P313
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P263 Kontakt w?hrend der Schwangerschaft /und der Stillzeit vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Acebutolol Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

Crystalline Solid

Verwenden

Cardioselective ?adrenergic blocker. Antihypertensive; antianginal; antiarrhythmic (class II)

Definition

ChEBI: An ether that is the 2-acetyl-4-(butanoylamino)phenyl ether of the primary hydroxy group of 3-(propan-2-ylamino)propane-1,2-diol.

Allgemeine Beschreibung

Acebutolol is one of the very few β-blockers whosemetabolite plays a significant role in its pharmacological actions.This drug is absorbed well from the gastrointestinaltract, but it undergoes extensive first-pass metabolic conversionto diacetolol by hydrolytic conversion of the amidegroup to the amine, followed by acetylation of the amine. After oral administration, plasma levels of diacetololare higher than those of acebutolol. Diacetolol is also aselective β1-blocker with partial agonistic activity; it has littlemembrane-stabilizing activity. It has a longer half-life (8–12hours) than the parent drug and is excreted by the kidneys.

Clinical Use

Acebutolol (Sectral) is a cardioselective 1-adrenoceptor blocking agent that also has some minor membrane stabilizing effects on the action potential. Acebutolol is effective in the management of the patient with essential hypertension, angina pectoris, and ventricular arrhythmias. Antiarrhythmic effects are observed with the patient both at rest and taking exercise.

Nebenwirkungen

Adverse effects include bradycardia, gastrointestinal upset, dizziness, and headache.

Sicherheitsprofil

Moderately toxic by intravenousroute. Human systemic effects by ingestion: developmentalabnormalities of the cardiovascular and respiratory systems;effects on newborn in biochemical and metabolicabnormalities and reduced growth statistics. A humanter

Stoffwechsel

About half of an orally administered dose of acebutolol (Sectral) is absorbed. Approximately 25% of the drug is bound to plasma proteins, and its plasma halflife is about 4 hours.Metabolism of acebutolol produces a metabolite with -blocking activity whose half-life is 10 hours.

Vorsichtsma?nahmen

Acebutolol should not be administered in cardiogenic shock, uncontrolled heart failure, or severe bradycardia or to patients with known hypersensitivity to the drug.

Acebutolol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Acebutolol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 67)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29810 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
sgtlifesciences pvt ltd
+8617013299288
dj@sgtlifesciences.com China 12373 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Mainchem Co., Ltd. +86-0592-6210733
sale@mainchem.com China 32343 55
Chemwill Asia Co.,Ltd. 86-21-51086038
chemwill_asia@126.com CHINA 23912 58
LGM Pharma 1-(800)-881-8210
inquiries@lgmpharma.com United States 2123 70
Syntechem Co.,Ltd
info@syntechem.com China 12984 57
China Langchem Inc. 0086-21-58956006
China 7811 57
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794
sales@hcshhai.com China 9793 50

37517-30-9(Acebutolol)Verwandte Suche:


  • (.+/-.)-3'-Acetyl-4'-[2-hydroxy-3-(1-methylethylamino)propoxy]butyranilide
  • (.+/-.)-3'-Acetyl-4'-[2-hydroxy-3-(isopropylamino)propoxy]butyranilide
  • (.+/-.)-N-(3-Acetyl-4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)butanamide
  • 1-(2-Acetyl-4-n-butyramidophenoxy)-2-hydroxy-3-isopropylaminopropane
  • 3'-Acetyl-4'-(2-hydroxy-3-(isopropylamino)propoxy)butyranilide
  • 5'-Butyramido-2'-(2-hydroxy-3-isopropylaminopropoxy)acetophenone
  • Butanamide, N-[3-acetyl-4-[2-hydroxy-3-[(1-methylethyl)amino]propoxy]phenyl]-, (.+/-.)-
  • dl-Acebutolol
  • N-(3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide
  • Prent
  • Sectral
  • ACEBUTOLOL
  • n-[3-acetyl-4-(2-hydroxy-3-propan-2-ylamino-propoxy)-phenyl]butanamide
  • Acebutolo HCl
  • Acebutololum
  • AcebutololDiscontinued. See: A123800
  • Acetobutolol
  • N-(3-acetyl-4-(2-hydroxy-3-(isopropylaMino)propoxy)phenyl)butyraMide
  • Acebutolol USP/EP/BP
  • Acebutolol D7Q: What is Acebutolol D7 Q: What is the CAS Number of Acebutolol D7 Q: What is the storage condition of Acebutolol D7
  • Acebuprolol
  • 37517-30-9
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Adrenoceptor
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