8-(4-CHLOROPHENYLTHIO)GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt has been used to activate GMP-dependent protein kinase (PKG) in vascular smooth muscle cells (VSMCs).
Biochem/physiol Actions
Membrane-permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to greater membrane permeability and a higher resistance to hydrolysis by phosphodiesterase. Used as a selective activator of cGMP dependent protein kinase (PKG). Found to be a very potent cyclic nucleotide-gated channel agonist.
8-(4-CHLOROPHENYLTHIO)GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte