Tetrabenazin
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- CAS-Nr.
- 58-46-8
- Bezeichnung:
- Tetrabenazin
- Englisch Name:
- Tetrabenazine
- Synonyma:
- Xenazine;Nitoman;Rubigen;Ro 1-9569;TETRABENAZINE;(3R,11bR)-rel-;TBZ,racemic mixture;TetrabezineImpurity5;Tetrabenazine(Xenazine);Butyl benzene that lamictal
- CBNumber:
- CB5339246
- Summenformel:
- C19H27NO3
- Molgewicht:
- 317.42
- MOL-Datei:
- 58-46-8.mol
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Tetrabenazin Eigenschaften
- Schmelzpunkt:
- 128-130?C
- Siedepunkt:
- 456.71°C (rough estimate)
- Dichte
- 1.12
- Brechungsindex
- 1.5180 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: >10mg/mL
- pka
- 6.46±0.40(Predicted)
- Aggregatzustand
- solid
- Farbe
- White
- Merck
- 14,9182
- BRN
- 40090
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 week.
- InChIKey
- MKJIEFSOBYUXJB-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Tetrabenazin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
Chemische Eigenschaften
White to Off-White Solid
Verwenden
Tetrabenazine has been used for dopamine uptake assays in mouse brain cells
1. Tetrabenazine has also been used for non-specific binding assays in postnuclear supernatants derived from PC-12 and CV-1 cells
2.
Definition
ChEBI: A benzoquinolizine that is 1,2,3,4,4a,9,10,10a-octahydrophenanthrene in which the carbon at position 10a is replaced by a nitrogen and which is substituted by an isobutyl group at position 2, an oxo group at position 3, and methoxy groups at positions 6 an
7.
Allgemeine Beschreibung
A cell permeable benzoquinolizine based compound that acts as a monoamine-depleting agent by blocking the activity vesicular monoamine transporter 2. Promotes late-stage differentiation of Pdx1-positive pancreatic progenitor cells into Neurog3 (Ngn3)-positive endocrine precursors without increasing their proliferation. Increases the number of insulin expressing cells in a dose dependent manner (EC
50 = 220 nM) and this effect is significantly enhanced when cells are simultaneously treated with dibutyryl cAMP. Embryonic stem cells treated with TBZ and/or dibutyryl cAMP and then grafted into kidney capsule of AKITA mice reduce hyperglycemia, improve fasting blood glucose levels, and show an increase in plasma C-peptide levels.
Biologische Aktivit?t
Potent inhibitor of vesicular monoamine uptake; depletes stores of dopamine, serotonin and noradrenalin. Binds with high affinity (IC 50 = 3.2 nM) to vesicular monoamine transporter (VMAT) in chromaffin granule membranes and displays higher affinity for VMAT2 than VMAT1. Also reported to block dopamine receptors. Causes behavioral depression; inhibits locomotor activity and produces hypothermia upon systemic administration in rats and mice.
l?uterung methode
Crystallise it from MeOH. The hydrochloride has m 208-210o, and the oxime has m 158o (from EtOH). [Beilstein 21 III/IV 6488.]
Tetrabenazin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
7-METHOXY-1,2,3,4-TETRAHYDRO-ISOQUINOLINE HYDROCHLORIDE
6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride
1,2,3,4-Tetrahydroisochinolin
(2-Acetyl-4-Methylpentyl)triMethylaMMoniuM Iodide
3,4-Dihydro-6,7-dimethoxyisochinolin
Downstream Produkte
Tetrabenazin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 259)Lieferanten
58-46-8(Tetrabenazin)Verwandte Suche:
- 1,3,4,6,7,11b-Hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-2H-benzo[a]quinolizin-2-one
- Nitoman
- Ro 1-9569
- Rubigen
- cis-9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a]quinolizin-2-one
- 3-isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydropyrido[2,1-a]isoquinolin-2-one
- 9,10-dimethoxy-3-(2-methylpropyl)-1,3,4,6,7,11b-hexahydropyrido[2,1-a]isoquinolin-2-one
- 3-Isobutyl-9,10-diMethoxy-3,4,6,7-tetrahydro-1H-pyrido[2,1-a]isoquinolin-2(11bH)
- (3R,11bR)-rel-
- 3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-benzo[a]quinolizin-2-one
- 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
- (3R,11BR)-REL-1,3,4,6,7,11B-HEXAHYDRO-9,10-DIMETHOXY-3-(2-METHYLPROPYL)-2H-BENZO[A]QUINOLIZIN-2-ONE
- TETRABENAZINE
- 2H-Benzo[a]quinolizin-2-one, 1,3,4,6,7,11b-hexahydro-9,10-dimethoxy-3-(2-methylpropyl)-, (3R,11bR)-rel-
- 9,10-Dimethoxy-1,3,4,6,7,11b-hexahydro-3-isobutyl-2H-benzo[a]quinolizin-2-one
- Tetrabenazine(Xenazine)
- Tetrabenazine Related Impurity 5
- Tetrabenazine, 99%, a VMAT-inhibitor
- TBZ,racemic mixture
- TETRABENAZINE ISO 9001：2015 REACH
- TetrabenazineQ: What is
Tetrabenazine Q: What is the CAS Number of
Tetrabenazine Q: What is the storage condition of
Tetrabenazine Q: What are the applications of
Tetrabenazine
- Xenazine
- Butyl benzene that lamictal
- TetrabezineImpurity5
- 2-amino-1-(7-bromophenyl)ethanol
- 13C2,2H6]-Tetrabenazine, racemic mixture
- rel-(3R,11bR)-3-Isobutyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one
- trans (2,3)-Dihydro Tetrabenazine-d6 (Isobutyl D6)
- Tetrabenazine, VMAT2 inhibitor
- Tetrabenazine, 10 mM in DMSO
- 58-46-8
- 164106-49-8
- Serotonin receptor
- APIs
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Other APIs
- 58-46-8
