2-AG
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2-AG Eigenschaften
- Siedepunkt:
- 508.6±50.0 °C(Predicted)
- Dichte
- 0.992±0.06 g/cm3(Predicted)
- Flammpunkt:
- 2 °C
- storage temp.
- -20°C
- L?slichkeit
- DMSO: 10 mg/ml; Ethanol: Miscible; PBS (pH 7.2): ~150 μg/ml
- Aggregatzustand
- acetonitrile solution
- pka
- 13.54±0.10(Predicted)
- Farbe
- Colorless to light yellow
- CAS Datenbank
- 53847-30-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher | F,Xn | ||
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R-S?tze: | 11-20/21/22-36 | ||
S-S?tze: | 26-36/37-16 | ||
RIDADR | UN 1648 3/PG 2 | ||
WGK Germany | 2 |
Bildanzeige (GHS) | ||||||||||||||||||||||
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Alarmwort | Achtung | |||||||||||||||||||||
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Sicherheit |
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2-AG Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R11:Leichtentzündlich.R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36:Reizt die Augen.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Verwenden
2-Arachidonoylglycerol is a major endocannabinoid, which can inhibit synaptic transmission by presynaptic cannabinoid CB1 receptors. It plays an inhibitory role in the bombesin-induced activation of central adrenomedullary outflow in rats.Definition
ChEBI: An endocannabinoid and an endogenous agonist of the cannabinoid receptors (CB1 and CB2). It is an ester formed from omega-6-arachidonic acid and glycerol.Allgemeine Beschreibung
2-Arachidonoylglycerol (2-AG), is an endocannabinoid, an endogenous agonist of the CB1 receptor. 2-AG, unlike anandamide, is present at relatively high levels in the central nervous system; it is the most abundant molecular species of monoacylglycerol found in mouse and rat brain (~5-10 nmol/g tissue). Detection of 2-AG in brain tissue is complicated by the relative ease of its isomerization to 1-AG during standard lipid extraction conditions. Unlike anandamide, formation of 2-AG is calcium-dependent and is mediated by the activities of phospholipase C (PLC) and diacylglycerol lipase (DAGL). 2-AG acts as a full agonist at the CB1 receptor. At a concentration of 0.3nM, 2-AG induces a rapid, transient increase in intracellular free calcium in NG108-15 neuroblastoma X glioma cells through a CB1 receptor-dependent mechanism. 2-AG is hydrolyzed in vitro by monoacylglycerol lipase (MAGL), fatty acid amide hydrolase (FAAH), and the uncharacterized serine hydrolase enzymes ABHD6 and ABHD12.Biologische Aktivit?t
Endogenous cannabinoid ligand that acts as a potent agonist at GPR55 (EC 50 values are 3, 519 and 618 nM at GPR55, CB 1 and CB 2 respectively; K i values are 472 and 1400 nM at CB 1 and CB 2 respectively). Found in the brain at concentrations 1000-fold higher than that of anandamide.Enzyminhibitor
This potent endocannabinoid (FW = 378.30 g/mol; CAS 53847-30-6; Symbol: 2-AG), also known as 1,3-dihydroxy-2-propanyl (5Z,8Z,11Z,14Z)- 5,8,11,14-eicosatetraenoate, is an endogenous agonist of the CB1, the G- protein-coupled Cannabinoid receptor type-1 found primarily in the central and peripheral nervous system. 2-AG is found at highest concentrations in the CNS, where it exerts its cannabinoid-like neuromodulatory effects. Found in milk, 2-AG plays a role in sustaining infant suckling, and the selective CB1 receptor antagonist SR141617A (N-(piperidin-1-yl)-5-(4- chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3- carboxamide) permanently prevents milk ingestion in a dose-dependent manner, when administered to mouse pups, within 1 day of birth. 2-AG is formed by phospholipase C (PLC) and diacylglycerol lipase (DAGL) from arachidonic acid-containing diacylglycerol (DAG). In the CNS, three serine-hydrolases, monoacylglycerol lipase (MAGL), a,b-hydrolase- domain-6 (ABHD6) and a,b-hydrolase-domain 12 (ABHD12) are responsible for inactivation of the primary 2-arachidonoylglycerol. Irreversible ABHD6 inhibitors show exceptional potency and selectivity in cells (<5 nM) and, at equivalent doses in mice (1 mg/kg), acting as systemic and peripherally restricted inhibitors, respectively. Indeed, selective knockdown of ABHD6 in metabolic tissues protects mice from high-fat-diet-induced obesity, hepatic steatosis, and systemic insulin resistance.2-AG Upstream-Materialien And Downstream Produkte
Upstream-Materialien
5,8,11,14-Eicosatetraenoic acid, 2-[(2,2,2-trifluoroacetyl)oxy]-1-[[(2,2,2-trifluoroacetyl)oxy]methyl]ethyl ester, (5Z,8Z,11Z,14Z)-
O-ARACHIDONOYL GLYCIDOL
1-STEAROYL-2-ARACHIDONOYL-SN-GLYCEROL
(5Z,8Z,11Z,14Z)-2-[[Tris(1-Methylethyl)silyl]oxy]-5,8,11,14-eicosatetraenoic Acid 1-[[[Tris(1-Methylethyl)silyl]oxy]Methyl]ethyl Ester
Icosa-5,8,11,14-tetraensure
Downstream Produkte
2-AG Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 71)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49734 | 58 |
TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38631 | 58 |
GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 49977 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 |
product@acmec-e.com | China | 33338 | 58 |
SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 |
cooperation@kean-chem.com | China | 40066 | 58 |
Mainchem Co., Ltd. | +86-0592-6210733 |
sale@mainchem.com | China | 32343 | 55 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 |
jkinfo@jkchemical.com | China | 96815 | 76 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15839 | 69 |
- 5Z,8Z,11Z,14Z-EICOSATETRAENOIC ACID, 2-GLYCERYL ESTER
- (5Z,8Z,11Z,14Z)-5,8,11,14-EICOSATETRAENOIC ACID, 2-HYDROXY-1-(HYDROXYMETHYL)ETHYL ESTER
- 2-AG
- NOLADIN
- (5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenoicacid
- 2-Hydroxy-1-(hydroxymethyl)ethylester
- 1,3-dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate
- 2-Ara-gl
- 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (5Z,8Z,11Z,14Z)-
- 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (all-Z)-
- 2-Arachidonyl Glycerol (90%)
- (all-Z)-5,8,11,14-Eicosatetraenoic Acid 2-Hydroxy-1-(hydroxyMethyl)ethyl Ester
- 2-Monoarachidonoylglycerol
- 2-Arachidonyl glycerol solution in acetonitrile
- 2-Arachidonylglycerol (acetonitrile solution)
- 2-Arachidonyl Glycerol (~70%)
- (5Z,8Z,11Z,14Z)-1,3-Dihydroxypropan-2-yl icosa-5,8,11,14-tetraenoate
- 2-ARACHIDONYLGLYCEROL
- 2-ARACHIDONOYLGLYCEROL
- Inhibitor,2 Arachidonoylglycerol,2-Arachidonoylglycerol,2Arachidonoylglycerol,Endogenous Metabolite,inhibit,Cannabinoid Receptor
- 2-Monoarachidonin
- 53847-30-6
- Cannabinoid
- Fatty Acid Derivatives & Lipids
- Glycerols
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Cannabinoid receptor