Csn-B
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- CAS-Nr.
- 321661-62-5
- Englisch Name:
- Csn-B
- Synonyma:
- Cytosporone B;Csn-B;Dothiorelone G;ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate;Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate;(3,5-Dihydroxy-2-octanoyl-phenyl)-acetic acid ethyl ester;3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester;3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester;Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester;N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBENZAMIDE
- CBNumber:
- CB52750977
- Summenformel:
- C18H26O5
- Molgewicht:
- 322.4
- MOL-Datei:
- 321661-62-5.mol
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Csn-B Eigenschaften
- Siedepunkt:
- 471.6±24.0 °C(Predicted)
- Dichte
- 1.126±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- L?slichkeit
- DMSO: >20mg/mL
- pka
- 7.54±0.40(Predicted)
- Aggregatzustand
- A crystalline solid
- Farbe
- white to off-white
- InChI
- InChI=1S/C18H26O5/c1-3-5-6-7-8-9-15(20)18-13(11-17(22)23-4-2)10-14(19)12-16(18)21/h10,12,19,21H,3-9,11H2,1-2H3
- InChIKey
- UVVWQQKSNZLUQA-UHFFFAOYSA-N
- SMILES
- C1(CC(OCC)=O)=CC(O)=CC(O)=C1C(=O)CCCCCCC
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn |
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| R-S?tze: |
22 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Csn-B Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Cytosporone B is a naturally occuring agonist for the nuclear receptor Nur77., induces the expression of Nur77-dependent genes including the gene for Nur77 itself. Induces apoptosis in cancer cells.
Biochem/physiol Actions
Cytosporone B (Csn-B) is the first naturally occurring agonist for nuclear orphan receptor Nur77. It binds with high affinity (IC50=0.278 nM) to the ligand-binding domain of Nur77 and stimulates Nur77-dependent activities. Nur77 is a nuclear receptor/transcription factor. A physiological ligand for Nur77 is as yet unknown, but there is increasing interest in Nur77 because of its known activities. Translocation of Nur77 from the nucleus to mitochondria initiates cell apoptosis, making it a potential target for cancer treatment. Nur77 is also involved in glucose homeostasis; it induces genes involved in gluconeogenesis. Csn-B physically binds to Nur77 and activates its transactivational activity and translocation to mitochondria to induce apoptosis. It inhibits cancer cell proliferation and tumor growth.
Csn-B Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Csn-B Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 100)Lieferanten
321661-62-5()Verwandte Suche:
- 3,5-Dihydroxy-2-(1-oxooctyl)benzeneacetic acid ethyl ester
- 3,5-Dihydroxy-2-(1-oxooctyl)-benzeneacetic acid, ethyl ester
- Csn-B
- ethyl 2-(3,5-dihydroxy-2-octanoylphenyl)acetate
- Benzeneacetic acid, 3,5-dihydroxy-2-(1-oxooctyl)-, ethyl ester
- N-{2-[(3-CYANO-5,7-DIMETHYL-2-QUINOLINYL)AMINO]ETHYL}-3-METHOXYBENZAMIDE
- Ethyl 3,5-dihydroxy-2-(1-oxooctyl)-benzeneacetate
- Dothiorelone G
- (3,5-Dihydroxy-2-octanoyl-phenyl)-acetic acid ethyl ester
- Cytosporone B
- 321661-62-5
