Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
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Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Eigenschaften
- storage temp.
- -20°C
- Aggregatzustand
- solid
- Farbe
- White to off-white
Sicherheit
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Kdo2-Lipid A (KLA) is a nearly homogeneous Re lipopolysaccharide (LPS) substracture with endotoxin activity equal to tha of native LPS. KLA is comparable to LPS and its activity is reduced by >10^3 in cells fro TLR-4 deficient mice.Allgemeine Beschreibung
3-deoxy-D-manno-octulosonic acid (Kdo2-Lipid A) is the essential component of lipopolysaccharide in most Gram-negative bacteria and the minimal structural component to sustain bacterial viability. It serves as the active component of lipopolysaccharide to stimulate potent host immune responses through the complex of Toll-like-receptor 4 (TLR4) and myeloid differentiation protein 2 (MD2). Therefore, Kdo2-lipid A is an important stimulator for studying the mechanism of the innate immune system and for developing bacterial vaccine adjuvants. Kdo2 Lipid A/TLR4 antagonists can also be applied in anti-inflammatory interventions. Kdo2-lipid A, induces de novo sphingolipid biosynthesis in RAW264.7 macrophages, which is essential for induction of autophagy. Kdo2-Lipid A has been used in animal atherosclerosis model.Biochem/physiol Actions
Kdo2-Lipid A might be useful to stimulate inflammatory response.Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 27)Lieferanten
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BOC Sciences | +1-631-485-4226 |
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Creative Enzymes | 1-516-855-7709 |
info@creative-enzymes.com | United States | 8748 | 58 |
TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38631 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 |
orderCN@merckgroup.com | China | 51456 | 80 |
Codow Chemical Co.,Ltd. | 18620099427 |
amy@howeipharm.com | China | 17687 | 55 |
Chengdu Dianchun Technology Co., Ltd | 400-1166-196 18502815961 |
cdhxsj@163.com | China | 14603 | 60 |
Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 |
3193328036@qq.com | China | 29764 | 68 |
BOC Sciences | 16314854226 |
inquiry@bocsci.com | United States | 9713 | 58 |
TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 24644 | 58 |
SHANGHAI ZZBIO CO., LTD. | 15102117276 19921389125 |
tech@zzbioco.com | China | 12065 | 58 |
- Di[3-deoxy-D-Manno-octulosonyl]-lipid A (aMMoniuM salt)
- O-3-Deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-4)-O-3-deoxy-alpha-D-altro-2-octulopyranosonosyl-(2-6)-O-2-deoxy-2-[[(3R)-1-oxo-3-[(1-oxododecyl)oxy]tetradecyl]amino]-3-O-[(3R)-1-oxo-3-[(1-oxotetradecyl)oxy]tetradecyl]-4-O-phosphono-beta-D-glucopyranosyl-(1-6)-2-deoxy-2-[[(3R)-3-hydroxy-1-oxotetradecyl]amino]-alpha-D-glucopyranose 1-(dihydrogen phosphate) 3-[(3R)-3-hydroxytetradecanoate] ammonium salt (1:4)
- DI[3-DEOXY-D-MANNO-OCTULOSONYL]-LIPID A (AMMONIUM SALT);KDO2-LIPID A
- Kdo2-Lipid A
- Di[3-deoxy-D-manno-octulosonyl]-lipid A sodium salt - 0.5mg/ml aqueous solution
- Kdo2-Lipid A (KLA)
- Kdo2-Lipid A ammonium
- 1246298-62-3
- C110H202N2O39P24NH3