GSA 10
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- CAS-Nr.
- 300833-95-8
- Englisch Name:
- GSA 10
- Synonyma:
- GSA 10;propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate;Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate;4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester;Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester;Inhibitor,differentiation,regenerative medicine,Smoothened receptor,quinolinecarboxamide derivative,cancer,Smoothened,GSA 10,GSA-10,Smo,osteoblasts,Hedgehog,GSA10,inhibit,multipotent mesenchymal progenitor cell
- CBNumber:
- CB52716245
- Summenformel:
- C26H30N2O5
- Molgewicht:
- 450.53
- MOL-Datei:
- 300833-95-8.mol
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GSA 10 Eigenschaften
- Siedepunkt:
- 620.2±55.0 °C(Predicted)
- Dichte
- 1.240±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- L?slichkeit
- Soluble to 5 mM in DMSO with gentle warming
- Aggregatzustand
- Powder
- pka
- 4.50±1.00(Predicted)
- Farbe
- White to light yellow
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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GSA 10 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Smoothened (SMO) is a cell surface receptor that, with Patched, mediates hedgehog signaling to regulate gene expression through the Gli transcription factors. GSA 10 is a quinolinecarboxamide derivative that acts as an agonist of SMO. By acting at SMO, GSA 10 has been shown to promote the differentiation of multipotent mesenchymal progenitor cells into osteoblasts (EC
50 = 1.2 μM). Most notably, GSA 10 does not recognize the classic cyclopamine binding site as do other SMO agonists and as such has been used to characterize a novel SMO active site.
Verwenden
GSA 10 is a novel small-molecule positive modulator of smoothened. GSA 10 may have therapeutic interests in regenerative medicine.
GSA 10 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
GSA 10 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 44)Lieferanten
- Propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
- GSA 10
- propyl 4-[(1-hexyl-4-hydroxy-2-oxo-quinoline-3-carbonyl)amino]benzoate
- 4-[[(1-Hexyl-1,2-dihydro-2-oxo-3-quinolinyl)carbonyl]amino]benzoic acid propyl ester
- Inhibitor,differentiation,regenerative medicine,Smoothened receptor,quinolinecarboxamide derivative,cancer,Smoothened,GSA 10,GSA-10,Smo,osteoblasts,Hedgehog,GSA10,inhibit,multipotent mesenchymal progenitor cell
- Benzoic acid, 4-[[(1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-3-quinolinyl)carbonyl]amino]-, propyl ester
- 300833-95-8
