UNC0646 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

G9a and G9a-like protein (GLP) are euchromatic histone-lysine methyltransferases (EHMT2 and EHMT1, respectively) that can heterodimerize with each other to methylate several proteins in addition to histone H3. UNC0646 is a potent and selective inhibitor of G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) and G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases. UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line. This compound selectively targets the corepressor function of G9a without affecting its ability to act as a coactivator with glucocorticoid receptor.

Verwenden

UNC0646 is a novel Protein lysine methyltransferase G9a inhibitor.

UNC0646 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

UNC0646 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30233	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
LEAPCHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	43340	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52924	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2922	55
Chembest Research Laboratories Limited	+86-21-20908456	sales@BioChemBest.com	China	6005	61

1320288-17-2()Verwandte Suche:

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• UNC0646
• N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-Methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-aMine
• UNC0646/UNC-0646
• N-(1-Cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
• N-(1-Cyclohexyl-4-piperidinyl)-2-(4-isopropyl-1,4-diazepan-1-yl)- 6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine
• (1-CYCLOHEXYL-PIPERIDIN-4-YL)-[2-(4-ISOPROPYL-[1,4]DIAZEPAN-1-YL)-6-METHOXY-7-(3-PIPERIDIN-1-YL-PROPOXY)-QUINAZOLIN-4-YL]-AMINE
• UNC 0646;UNC0646;UNC-0646
• CS-792
• 4-Quinazolinamine, N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-
• H3K9me2,KMT1D,chromatin,EHMT1,Histone Methyltransferase,UNC-0646,SAR,inhibit,G9a,GLP,PKMT,UNC0646,Inhibitor,cell-penetration,p53
• N-(1-cyclohexylpiperidin-4-yl)-6-methoxy-7-[3-(piperidin-1-yl)propoxy]-2-[4-(propan-2-yl)-1,4-diazepan-1-yl]quinazolin-4-amine
• UNC0646, 10 mM in DMSO
• 1320288-17-2
• C36H59N7O2