KGN
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- CAS-Nr.
- 4727-31-5
- Englisch Name:
- KGN
- Synonyma:
- KGN;CS-612;100822;Kartogenin;KGN USP/EP/BP;Kartogenin(KGN);Kartogenin, 10 mM in DMSO;4'-Phenylphthalanilic Acid;CBFβ Activator, Kartogenin;n-Biphenyl-4-yl-phthalamic acid
- CBNumber:
- CB52622751
- Summenformel:
- C20H15NO3
- Molgewicht:
- 317.34
- MOL-Datei:
- 4727-31-5.mol
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KGN Eigenschaften
- Schmelzpunkt:
- 272 °C
- Siedepunkt:
- 464.4±38.0 °C(Predicted)
- Dichte
- 1.289±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- DMSO: >15mg/mL
- Aggregatzustand
- powder
- pka
- 3.45±0.36(Predicted)
- Farbe
- White
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChIKey
- SLUINPGXGFUMLL-UHFFFAOYSA-N
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn,N |
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| R-S?tze: |
22-36-50/53 |
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| S-S?tze: |
60-61 |
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| RIDADR |
UN 3077 9 / PGIII |
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| WGK Germany |
3 |
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| HS Code |
2916310090 |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H410 |
Sehr giftig für Wasserorganismen mit langfristiger Wirkung. |
Langfristig (chronisch) gew?ssergef?hrdend |
Kategorie 1 |
Warnung |
![GHS hazard pictograms]() src="/GHS09.jpg" width="20" height="20" /> |
P273, P391, P501 |
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| Sicherheit |
| P273 |
Freisetzung in die Umwelt vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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KGN Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Kartogenin potently induces differentiation of human mesenchymal stem cells into chondrocytes with an EC
50 value of 100 nM. Kartogenin induces chondrogenesis by binding the actin-
binding protein, filamin A, which disrupts its interaction with the transcription factor core-
binding factor β subunit (CBFβ). When dissociated from filamin A, CBFβ translocates to the nucleus and forms a transcriptional complex with the runt-
related transcription factor RUNX1, which enables chondrocyte differentiation. Kartogenin has been shown to promote cartilage repair in a mouse model of osteoarthritis and to protect against cytokine-
induced damage in osteoarthritic bovine articular chondrocytes
in vitro.
Verwenden
Kartogenin is a potent, selective, and non-cytotoxic downstream RUNX1 and RUNX2 modulator. Kartogenin causes mesenchymal stem cells found in joints to differentiate into chondrocyte cells that can build cartilage where it has been destroyed.
Biochem/physiol Actions
Kartogenin induces the selective differentiation of multipotent mesenchymal stem cells (MSCs) into chondrocytes. Kartogenin binds to filamin A, and disrupts the specific interaction between filamin A and CBFβ (core-binding factor β subunit). Apparently, kartogenin induces chondrogenesis by regulating the nuclear localization of CBFβ.
KGN Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
KGN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 166)Lieferanten
4727-31-5()Verwandte Suche:
- 2-[([1,1'-Biphenyl]-4-ylaMino)carbonyl]benzoic Acid
- 2-[(Biphenyl-4-yl)carbaMoyl]benzoic Acid
- Kartogenin(KGN)
- 4'-Phenylphthalanilic Acid
- Kartogenin
- KGN
- 4′-Phenyl-phthalanilic acid (8CI)
- n-Biphenyl-4-yl-phthalamic acid
- 100822
- CS-612
- 2-[(4-phenylphenyl)carbamoyl]benzoic Acid
- Benzoic acid, 2-[([1,1'-biphenyl]-4-ylamino)carbonyl]-
- KGN USP/EP/BP
- 2-([1,1'-biphenyl]-4-ylcarbamoyl)benzoic acid
- 2-(4-Biphenylylcarbamoyl)benzoic Acid
- Kartogenin, stem cell differentiation
- Kartogenin, 10 mM in DMSO
- CBFβ Activator, Kartogenin
- 4727-31-5
- Inhibitors
- API
