2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
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- CAS-Nr.
- 442633-00-3
- Englisch Name:
- 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
- Synonyma:
- CK 666;CK-0944666;CK 666
(CK 0944666);Arp2/3 Complex Inhibitor I, CK-666;2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide;Benzamide, 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-;Inhibitor,HIV,meshwork,CK-666,Actin-related protein 2/3 complex,allosteric,CK 666,state,effector,active,inhibit,CK666,trabecular,Human immunodeficiency virus,Arp2/3 Complex
- CBNumber:
- CB52518908
- Summenformel:
- C18H17FN2O
- Molgewicht:
- 296.34
- MOL-Datei:
- 442633-00-3.mol
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2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide Eigenschaften
- Siedepunkt:
- 528.2±50.0 °C(Predicted)
- Dichte
- 1.235±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥25mg/mL
- pka
- 13.86±0.46(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to tan
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xi |
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| R-S?tze: |
36 |
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| S-S?tze: |
26 |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
CK-666 may be used to study Arp2/3-mediated structural changes in cells.
Allgemeine Beschreibung
A cell-permeable indolyl-fluorobenzamide compound that selectively inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human, bovine, fission yeast
S. pombe, and budding yeast
S. cerevisiae origin (IC
50 = 4, 17, 5, and 12 μM, respectively), without affecting
S. pombe formin domain Cdc12(FH2)-mediated or the spontaneous actin polymerization. Shown to inhibit the actin filament "comet tails" formation around intracellular
Listeria in infected SKOV3 cells (IC
50 = 7 μM) in a reversible manner. Structrual studies indicate that CK-666 targets a pocket formed between subdomain 4 of Arp2 and subdomain 1 of Arp3, preventing Arp2/3 from shifting into an active conformation upon N-WASP-VCA binding. CK-666 and CK-869 (Cat. No.
182516) exhibit different modes of binding, resulting in their different yeast cross-reactivities. CK-689 (Cat. No.
182517) can serve as a negative control.
Biochem/physiol Actions
CK-666 binds to Arp2/3 complex, stabilizes the inactive state of the complex and prevents its movement into active conformation.
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 61)Lieferanten
- 2-Fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]benzamide
- CK 666
- CK-0944666
- Arp2/3 Complex Inhibitor I, CK-666
- CK 666
(CK 0944666)
- Benzamide, 2-fluoro-N-[2-(2-methyl-1H-indol-3-yl)ethyl]-
- Inhibitor,HIV,meshwork,CK-666,Actin-related protein 2/3 complex,allosteric,CK 666,state,effector,active,inhibit,CK666,trabecular,Human immunodeficiency virus,Arp2/3 Complex
- 442633-00-3
