Akt Inhibitor X
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- CAS-Nr.
- 925681-41-0
- Englisch Name:
- Akt Inhibitor X
- Synonyma:
- 10-NCP;10-DEBC HCl;Akt Inhibitor X;10-NCP
(10-DEBC;SVKSJUIYYCQZEC-UHFFFAOYSA-N;N-diethyl-10H-phenoxazine-10-butanamine;2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride (1:1)
- CBNumber:
- CB52503238
- Summenformel:
- C20H26Cl2N2O
- Molgewicht:
- 381.34
- MOL-Datei:
- 925681-41-0.mol
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Akt Inhibitor X Eigenschaften
- storage temp.
- Store at -20°C
- L?slichkeit
- Soluble in DMSO
- Aggregatzustand
- Powder
- Farbe
- White to off-white
- Wasserl?slichkeit
- Soluble to 100mM in water or DMSO
- Sensitive
- Light Sensitive & Hygroscopic
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Akt Inhibitor X Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Akt functions as a key component in multiple signaling pathways to promote cell survival by mediating resistance to apoptosis. Akt inhibitor X is a cell permeable phenoxazine derivative that suppresses insulin-
like growth factor 1 (IGF-
1)-
stimulated phosphorylation of Akt with an IC
50 value of 1-
2 μM. This compound has been shown to block IGF-
1-
stimulated nuclear translocation of Akt in Rh1 cells and to inhibit the growth of Rh1, Rh18, and Rh30 cells with IC
50 values of 2-
5 μM. Inhibition of Akt phosphorylation by 5 μM of this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.
Verwenden
Akt Inhibitor X is used as a cell-permeable, reversible, and selective inhibitor of the phosphorylation of Akt and its in vitro kinase activity.
Akt Inhibitor X Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Akt Inhibitor X Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 49)Lieferanten
- Akt Inhibitor X
- 10-DEBC HCl
- 2-Chloro-N,N-diethyl-10H-phenoxazine-10-butanamine hydrochloride (1:1)
- N-diethyl-10H-phenoxazine-10-butanamine
- 10-NCP
- 10-NCP
(10-DEBC
- SVKSJUIYYCQZEC-UHFFFAOYSA-N
- 925681-41-0
- C20H25ClN2OHCl
