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Egrifta

Egrifta Struktur
804475-66-9
CAS-Nr.
804475-66-9
Englisch Name:
Egrifta
Synonyma:
Th-9507;Th 9507;Egrifta;Tesamerelin;Unii-mqg94m5eeo;High Pure Peptides Th9507 Tesamorelin Powder 2mg/Vial
CBNumber:
CB52493342
Summenformel:
C221H366N72O67S
Molgewicht:
5135.77794
MOL-Datei:
804475-66-9.mol

Egrifta Eigenschaften

InChIKey
QBEPNUQJQWDYKU-BMGKTWPMSA-N

Sicherheit

Egrifta Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Tesamorelin acetate is an analog of growth hormone-releasing hormone (GHRH) that was approved in the United States in 2010 for treatment of lipodystrophy in HIV patients. Tesomorelin is an analog of GHRH. GHRH stimulates the synthesis and release of GH. In the pituitary, GH is secreted in a pulsatile manner. GH control is regulated by somatostatin and the negative feedback regulator, IGF-1. Direct administration of GH to patients with lipodystrophy decreases VAT but has associated side effects such as fluid retention and joint swelling. Because of the side effects associated with direct GH administration, GHRH represents a attractive mechanism for increasing GH levels. Tesomorelin is an analog of GHRH in which the N-terminal amino acid, Tyr, is amidated with a trans-3-hexenoyl group. Capping of the N-terminus protects GHRH from cleavage by DPP-4. Tesomorelin demonstrates enhanced stability compared with GHRH in animal models.

Originator

Theratechnologies (Canada)

Verwenden

Egrifta (Tesamorelin) is used to reduce excess abdominal fat in HIV-infected lipodystrophy patients. Some HIV medicines cause this side effect (increased fat in the upper back and abdomen and decreased fat in the arms and legs.) Tesamorelin works by making the body produce more growth hormone. This medicine should not be used for weight loss.

Trademarks

Egrifta

Egrifta Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Egrifta Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • Th 9507
  • Th-9507
  • Unii-mqg94m5eeo
  • High Pure Peptides Th9507 Tesamorelin Powder 2mg/Vial
  • Tesamerelin
  • Egrifta
  • 804475-66-9
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