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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Struktur
141942-85-0
CAS-Nr.
141942-85-0
Englisch Name:
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonyma:
ATS-5;ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE;RETINCIC ACID;Ethyl (R)-(-)-4-cyan;(R)-Ethyl 4-cyano-3-;Ats-5(For Atorvastatin);Atorvastatin Impurity 127;Atorvastatin Impurity 166;)-4-cyano-3-hydroxybutyrate;(R)-4-cyano-3-hydroxybutyric
CBNumber:
CB5188978
Summenformel:
C7H11NO3
Molgewicht:
157.17
MOL-Datei:
141942-85-0.mol

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Eigenschaften

alpha 
-5 º (neat)
Siedepunkt:
270 °C(lit.)
Dichte
1.114 g/mL at 25 °C(lit.)
Brechungsindex
n20/D 1.448(lit.)
Flammpunkt:
>230 °F
storage temp. 
2-8°C
L?slichkeit
Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
Aggregatzustand
Liquid
pka
13.03±0.20(Predicted)
Farbe
Colorless to yellow
Wichte
1.114
Optische Aktivit?t
[α]25/D 5°, neat
BRN 
5328715
InChIKey
LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS Datenbank
141942-85-0(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38
S-S?tze: 26-36
WGK Germany  1
HS Code  29269090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P337+P313 Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Chemische Eigenschaften

yellow liquid

Application

Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Butanoic acid, 4-cyano-3-hydroxy-, (3R)- Ethyl 4-bromo-3-hydroxybutyrate Natriumcyanid Ethanol Ethyl-4-chloracetoacetat

Downstream Produkte

(3R,5R)-6-Cyano-3,5-dihydroxy-hexanoic Acid tert-Butyl Ester

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 423)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Jiangxi Sunway Chemical Co., Ltd.
+86-0794-5259909 +8615888611133
 dave@jxswchem.com China 22 58
Jiangxi Sunway Chemical Co., Ltd.
+86-0794-5259909 +8615888611133
 dave@jxswchem.com China 22 58
Hebei Mojin Biotechnology Co., Ltd 		+86 13288715578 +8613288715578
 sales@hbmojin.com China 12840 58
Hebei Chuanghai Biotechnology Co,.LTD 		+86-13131129325
 sales1@chuanghaibio.com China 5893 58
Hebei Dangtong Import and export Co LTD 		+86-13910575315 +86-13910575315
 admin@hbdangtong.com China 1000 58
Hangzhou ICH Biofarm Co., Ltd 		+86-0571-28186870; +undefined8613073685410
 sales@ichemie.com China 998 58
hebei hongtan Biotechnology Co., Ltd 		+86-86-1913198-3935 +8617331935328
 sales03@chemcn.cn China 970 58
Capot Chemical Co.,Ltd. 		+86-（0）57185586718 +86-13336195806
 sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd 		+86-371-66670886
info@dakenam.com China 18781 58
Henan Tianfu Chemical Co.,Ltd. 		+86-0371-55170693 +86-19937530512
 info@tianfuchem.com China 21634 55

141942-85-0()Verwandte Suche:

  • (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
  • (R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
  • (R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE
  • (R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE
  • (S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
  • ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE
  • ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE
  • ETHYL-(R)-(+)-4-CYANO-3-HYDROXYBUTANOATE
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
  • ETHYL (R)-(-)-4-CYANO-3-HYDROXYBUTYRATE
  • ETHYL (R)-4-CYANO-3-HYDROXYBUTYRATE
  • BUTANOIC ACID, 4-CYANO-3-HYDROXY-, ETHYL ESTER, (R)
  • BUTANOIC ACID 4-CYANO-3-HYDROXY-ETHYL ESTER, (S)
  • thyl (R)-(-)-4-Cyano-3-Hydroxy Butyate
  • (3R)-4-cyano-3-hydroxybutyric acid ethyl ester
  • FEthyl (R)-(-)-4-cyano-3-hydroxybutyrate
  • Atorvastatin interMediates Ats-5 (R)-4-cyano-3-hydrobutyric acid ethyl ester
  • Butanoic acid, 4-cyano-3-hydroxy-, ethyl ester, (3R)-
  • (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester
  • ethyle(R)-4-cyano-3-hydroxybutanoate
  • (R)-4-Cyano-3-hydroxy butanoate
  • (R)-4-cyano-3-hydroxybutyric
  • R(-)-4-cyano-3-hydroxybutyrtc ethyl ester
  • ATS-5:(R)ETHYL-4-CYANO-3-HYCLROXY BUTANCATE
  • R(-)4-CYANO-3-HYDROXYBUTYRIC ETHYL ESTER
  • R(-)-4-CYANO-3-HYDROXYBUTYRTC ETHYL ESTER /ATS-5
  • R(-)-4-Cyano-3-hydroxubutyricethylester
  • (R)-4-Cyano-3-hydroxybuttersureethylester
  • (R)-4-cyano-3-hydrobutyric acid ethyl ester
  • (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
  • RETINCIC ACID
  • [R]-[-]-Ethyl-cyano-3-hydroxybutyrate
  • (R)-(-)-4-Cyano-3-hydroxybutyratic acid, ethyl ester
  • Ethyl (R)-4-cyano-3-hydroxybutanoate,99%
  • Ethyl (R)-4-cyano-3-hydroxybutanoate,95%
  • Atorvastatincalcium(R)-4-cyano-3-hydrobutyric Acid Ethyl Ester
  • Ethyl (R)-(-)-4-cyan
  • 4-Cyano-3-hydroxy-butyric acid ethyl ester
  • )-4-cyano-3-hydroxybutyrate
  • Ethyl-(R)-4-(-)-cyano-3-hydroxybutyrate(C-1)
  • (R)-Ethyl 4-cyano-3-
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0]
  • Ats-5(For Atorvastatin)
  • Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate >
  • (R)-(-)-4-Cyano-3-hydroxybutyrate
  • Atorvastatin Impurity 127
  • (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl
  • (R)-(-)-4-CYANO-3-HYDROXYBUTYATE
  • (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl EsterQ: What is (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the CAS Number of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the storage condition of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester
  • ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE
  • ATS-5
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate(ATS-5)
  • Atorvastatin calcium impurity 63
  • Atorvastatin Impurity 166
  • ethyl (R)-3-hydroxy-4-cyano-butyrate
  • 141942-85-0
  • 41942-85-0
  • NCCH2CHOHCH2CO2C2H5
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