4-Chlor-7-nitrobenzo-2-oxa-1,3-diazol
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- CAS-Nr.
- 10199-89-0
- Bezeichnung:
- 4-Chlor-7-nitrobenzo-2-oxa-1,3-diazol
- Englisch Name:
- 4-Chloro-7-nitrobenzofurazan
- Synonyma:
- NBD-CL;4-chloro-7-nitrobenzo[c][1,2,5]oxadiazole;4-Chloro-7-nitro-1,2,3-benzoxadiazole;4-CHLORO-7-NITROBENZOFURAZAN;NBD CHLORIDE;4-chloro-7-nitrobenzo-2,1,3-oxadiazole;7-CHLORO-4-NITROBENZO-2-OXA-1,3-DIAZOLE;4-CHLORO-7-NITROBENZOFURAZAN, FOR FLUORE SCENCE;NBC-1;nbd-c1
- CBNumber:
- CB5173637
- Summenformel:
- C6H2ClN3O3
- Molgewicht:
- 199.55
- MOL-Datei:
- 10199-89-0.mol
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4-Chlor-7-nitrobenzo-2-oxa-1,3-diazol Eigenschaften
- Schmelzpunkt:
- 97-99 °C(lit.)
- Siedepunkt:
- 333.1±45.0 °C(Predicted)
- Dichte
- 2.0589 (rough estimate)
- Brechungsindex
- 1.5810 (estimate)
- storage temp.
- Inert atmosphere,Room Temperature
- L?slichkeit
- Soluble in methanol, dimethylsulfoxide, dimethylformamide and chloroform.
- pka
- -5.65±0.50(Predicted)
- Aggregatzustand
- Crystalline Powder
- Farbe
- Yellow to light brown
- Wasserl?slichkeit
- soluble
- BRN
- 614212
- CAS Datenbank
- 10199-89-0(CAS DataBase Reference)
- EPA chemische Informationen
- 2,1,3-Benzoxadiazole, 4-chloro-7-nitro- (10199-89-0)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
Xn,Xi |
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| R-S?tze: |
22-36/38 |
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| S-S?tze: |
36/37/39 |
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| RIDADR |
UN 2811 6.1/PG 3 |
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| WGK Germany |
3 |
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| RTECS-Nr. |
DF8002400 |
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| F |
10-21 |
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| TSCA |
Yes |
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| HS Code |
29349990 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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4-Chlor-7-nitrobenzo-2-oxa-1,3-diazol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/38:Reizt die Augen und die Haut.
S-S?tze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
yellow to light brown crystalline powder
Verwenden
4-Chloro-7-nitrobenzofurazan is nonfluorescent until it reacts with primary or secondary amines to produce a fluorescent product. 4-Chloro-7-nitrobenzofurazan has been extensively used as a derivatizing reagent for chromatography analysis of amino acids and low molecular weight amines.
Definition
ChEBI: A benzoxadiazole that is 2,1,3-benzoxadiazole which is substituted at position 4 by chlorine and at position 7 by a nitro group.
Allgemeine Beschreibung
4-Chloro-7-nitrobenzofurazan (NBD-Cl) is a highly sensitive chromogenic and fluorogenic reagent. It is reported to react spontaneously with
trans-1-methoxy-3-(trimethylsilyloxy)-1,3-butadiene (Danishefsky′s diene), to afford regioselectively the silyl enol ether, via normal electron-demand Diels-Alder (NEDDA) reaction. A study of the molecular structure, vibrational spectra and NBO (Natural Bond Orbital) analysis of NBD–Cl has been undertaken. Its utility as a pre-column derivatization agent has been examined.
l?uterung methode
Wash the solid with H2O, and it recrystallises from aqueous EtOH (1:1) as pale yellow needles. It sublimes in a vacuum [Gosh & Whitehouse Biochem J 108 155 1968, UV, NMR: Bolton et al. J Chem Soc 1004 1966].
4-Chlor-7-nitrobenzo-2-oxa-1,3-diazol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-Chlor-7-nitrobenzo-2-oxa-1,3-diazol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 244)Lieferanten
10199-89-0(4-Chlor-7-nitrobenzo-2-oxa-1,3-diazol)Verwandte Suche:
- 7-CHLORO-4-NITROBENZ-2-OXA-1-3-DIAZOLECR YSTALLINE
- 4-Chloro-7-nitrobenzo-2,1,3-oxadiazole~NBDchloride
- 2,1,3-Benzoxadiazole, 4-chloro-7-nitro-
- NBD-Cl (=4-Chloro-7-nitro-2,1,3-benzoxadiazole) [for HPLC Labeling]
- 4-chloro-7-nitrobenzofurazane
- 4-Chloro-7-nitro-1,2,3-benzoxadiazole, NBD-chloride
- NBC-1
- NBD chloride,98%
- NBD-Cl (=4-Chloro-7-nitro-2,1,3-benzoxadiazole)
- 4-Chloro-7-nitro-1,2
- 7-Chloro-4-nitro-2,1,3-benzoxadiazole
- NSC 228140
- 4-Chloro-7-nitrobenzofurazan
4-Chloro-7-nitro-2,1,3-benzoxadiazole
- 4-chloro-7-nitro-benzofuraza
- 4-nitro-7-chlorobenzofurazan
- nbd-c1
- 7-CHLORO-4-NITRO-2,1,3-BENZOXADIAZOL
- 7-CHLORO-4-NITROBENZOFURAZAN
- AKOS BC-0686
- 4-CHLORO-7-NITRO-2,1,3-BENZOXADIAZOLE
- 4-CHLORO-7-NITROBENZ-2-OXA-1,3-DIAZOLE
- 4-CHLORO-7-NITRO-BENZO[1,2,5]OXADIAZOLE
- 4-CHLORO-7-NITROBENZO-2-OXA-1,3-DIAZOLE
- 4-CHLORO-7-NITROBENZUFURAZAN
- 4-Chloro-7-nitro-1,2,3-benzoxadiazole (NBD-Cl )
- 4-Chloro-7-nitrobenzo-2-furazan, NBF-Cl
- 1-Chloro-4-nitrobenzoxadiazole
- LABOTEST-BB LT00238516
- TIMTEC-BB SBB005345
- 7-CHLORO-4-NITROBENZ-2-OXA-1,3-DIAZOLE
- Benzofurazan, 4-chloro-7-nitro-
- Shokat-update-comp17
- 4-Chloro-7-nitro-2,1,3-benzoxadiazole 99%
- NBD-Cl [4-Chloro-7-nitrobenzofurazan] *CAS 10199-89-0*
- NBD-Cl (=4-Chloro-7-nitro-2,1,3-benzoxadiazole)[for HPLC Labeling]>
- NBD-Cl [4-Chloro-7-nitrobenzofurazan
- oro-7-nitrobenzo-2-oxa-1,3-diazoL
- 4-CHLORO-7-NITROBENZOFURAZAN, FOR FLUORE SCENCE
- 4-chloro-7-nitrobenzo-2,1,3-oxadiazole
- 4-chloro-7-nitrobenzo[c][1,2,5]oxadiazole
- 7-CHLORO-4-NITROBENZO-2-OXA-1,3-DIAZOLE
- 4-CHLORO-7-NITROBENZOFURAZAN
- NBD CHLORIDE
- NBD-CL
- 4-Chloro-7-nitro-1,2,3-benzoxadiazole
- 4-Chloro-7-nitro-2,1,3-benzoxadiazole(NBD-Cl)
- 4-Choro-7-nitrobenzofurazan
- 4-Chloro-7-nitrobenzo-2-furazan
- 4-Chloro-7-nitrobenzo-2-oxa-1,3-oxadiazole
- NBD-Cl, Amine-reactive fluorogenic dye
- 10199-89-0
- C6H2ClN3O3
- Mercapto Group Labeling Reagents for Fluorescence HPLC
- HPLC Labeling Reagents
- Fluorescence Detection (HPLC Labeling Reagents)
- Amino Group Labeling Reagents for Fluorescence HPLC
- Functional Group Reactive Labels
- Functional Group Reactive Labels for Immunoassays
