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Posatirelin

Posatirelin Struktur
78664-73-0
CAS-Nr.
78664-73-0
Englisch Name:
Posatirelin
Synonyma:
RGH-2202;BRN6006446;BRN 6006446;BRN-6006446;Posatirelin;Posatirelinum;N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2;L-Prolinamide, (2S)-6-oxo-2-piperidinecarbonyl-L-leucyl-;N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide
CBNumber:
CB51179553
Summenformel:
C17H28N4O4
Molgewicht:
352.432
MOL-Datei:
78664-73-0.mol

Posatirelin Eigenschaften

Schmelzpunkt:
214-216°
alpha 
D25 -80.2° (c = 1 in acetic acid)
Siedepunkt:
739.6±60.0 °C(Predicted)
Dichte
1.214±0.06 g/cm3(Predicted)
pka
13.56±0.20(Predicted)

Sicherheit

Posatirelin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Posatirelin is a TRH analogue. In a rat experimental model of brain cholinergic decit by lesion of the nucleus basalis magnocellularis (nbM), posatirelin treatment rescued cholinergic neurones of the nbM and their cholinergic projections to the cerebral cortex (Sabbatini et al., 1998). Posatirelin has been used in AD and VaD patients (Parnetti et al., 1995, 1996). VaD patients treated with posatirelin showed a signicant improvement in intellectual performance, orientation, motivation and memory as compared to controls. e drug was well tolerated.

Verwenden

Posatirelin is a thyrotropin-releasing hormone analogue, used in the treatment of seizures and some neurodegenerative disease such as vascular dementia and Parkinson''s disease.

Posatirelin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Posatirelin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 8)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Jiangsu Hongmin Pharmaceutical Co., Ltd. 18221292452
fannieliu@glschina.com China 6798 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627
customer_service@efebio.com China 11974 58
TargetMol Chemicals Inc. 15002134094
marketing@targetmol.cn China 19700 58

  • Posatirelin
  • N-[(S)-6-Oxo-2-piperidinylcarbonyl]-L-Leu-L-Pro-NH2
  • RGH-2202
  • N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide
  • BRN 6006446
  • BRN6006446
  • BRN-6006446
  • Posatirelinum
  • L-Prolinamide, (2S)-6-oxo-2-piperidinecarbonyl-L-leucyl-
  • 78664-73-0
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