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LEVCROMAKALIM

LEVCROMAKALIM Struktur
94535-50-9
CAS-Nr.
94535-50-9
Englisch Name:
LEVCROMAKALIM
Synonyma:
brl38227;lemakalim;Brn 3622889;levcromakelim;LEVCROMAKALIM;LevkroMakaliM;(3s-trans)-yrrolidinyl);Levcromakalim, KATP channel activator;Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim;(3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
CBNumber:
CB5104507
Summenformel:
C16H18N2O3
Molgewicht:
286.33
MOL-Datei:
94535-50-9.mol

LEVCROMAKALIM Eigenschaften

Schmelzpunkt:
242-244°
alpha 
D26 -52.2° (c = 1 in chloroform)
Siedepunkt:
482.3±45.0 °C(Predicted)
Dichte
1.31±0.1 g/cm3(Predicted)
storage temp. 
Store at RT
L?slichkeit
DMSO: ≤10 mM, soluble
pka
13.18±0.60(Predicted)
Aggregatzustand
solid
Farbe
White to off-white

Sicherheit

S-S?tze: 22-24/25
WGK Germany  3
RTECS-Nr. DJ2177500

LEVCROMAKALIM Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Verwenden

Levcromakalim is a potassium channel activator and vasorelaxant used in the management of hypertension in diabetes mellitus.

Biologische Aktivit?t

Active enantiomer of the prototypical K ATP channel opener cromakalim (trans-3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-2H-1-benzopyran-6-carbonitrile ). Hypotensive and airways relaxant. IC 50 = 490 nM in guinea pig trachea.

LEVCROMAKALIM Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

LEVCROMAKALIM Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 55)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hangzhou FandaChem Co.,Ltd. 		+8615858145714
 FandaChem@Gmail.com China 8946 55
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
Changzhou PBpharmaceutical R&D Co.,Ltd 		0519-83990708
info@pbpharm.com CHINA 498 58
TopScience Biochemical 		00852-68527855
info@itopbiochem.com China Hong Kong 902 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4861 58
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60

94535-50-9()Verwandte Suche:

  • (3S,4R)-3,4-DIHYDRO-3-HYDROXY-2,2-DIMETHYL-4-(2-OXO-1-PYRROLIDINYL)-2H-1-BENZOPYRAN-6-CARBONITRILE
  • (3s-trans)-yrrolidinyl)
  • LEVCROMAKALIM
  • 2h-1-benzopyran-6-carbonitrile,3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-p
  • brl38227
  • lemakalim
  • levcromakelim
  • (3S,4R)-3β-Hydroxy-4-(2-oxopyrrolizino)-2,2-dimethyl-3,4-dihydro-6-cyano-2H-1-benzopyran
  • (3β,4α)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)-2H-1-benzopyran-6-carbonitrile
  • (3β,4α)-3-Hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
  • 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,trans)-
  • Brn 3622889
  • LevkroMakaliM
  • (3S,4R)-3-hydroxy-2,2-dimethyl-4-(2-oxopyrrolidin-1-yl)chroman-6-carbonitrile
  • 2H-1-Benzopyran-6-carbonitrile, 3,4-dihydro-3-hydroxy-2,2-dimethyl-4-(2-oxo-1-pyrrolidinyl)-, (3S,4R)-
  • Potassium Channel,KcsA,Inhibitor,inhibit,BRL38227,BRL-38227,Levcromakalim
  • Levcromakalim, KATP channel activator
  • 94535-50-9
  • Ion Channels
  • Monovalent Ion Channels
  • Potassium Channel Modulators
  • Voltage-gated Ion Channels
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
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