6-BROMO-2,4-DICHLOROQUINAZOLINE
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- CAS-Nr.
- 102393-82-8
- Englisch Name:
- 6-BROMO-2,4-DICHLOROQUINAZOLINE
- Synonyma:
- 4-dichloroquinazoline;6-Bromo-2,4-dichloroquina...;6-broMo-2,4-dichlroquinazoline;2,4-Dichloro-6-broMoquinazoline;6-BROMO-2,4-DICHLOROQUINAZOLINE;Quinazoline, 6-bromo-2,4-dichloro-;6-Bromo-2,4-dichloroquinazoline,97%
- CBNumber:
- CB51012890
- Summenformel:
- C8H3BrCl2N2
- Molgewicht:
- 277.93
- MOL-Datei:
- 102393-82-8.mol
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6-BROMO-2,4-DICHLOROQUINAZOLINE Eigenschaften
- Siedepunkt:
- 330.2±24.0 °C(Predicted)
- Dichte
- 1.851±0.06 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,Store in freezer, under -20°C
- pka
- -1.19±0.30(Predicted)
- Aggregatzustand
- Solid
- Farbe
- Off-white
- Wasserl?slichkeit
- Slightly soluble in water.
- InChI
- InChI=1S/C8H3BrCl2N2/c9-4-1-2-6-5(3-4)7(10)13-8(11)12-6/h1-3H
- InChIKey
- LBAYOWRVZAKPLS-UHFFFAOYSA-N
- SMILES
- N1=C2C(C=C(Br)C=C2)=C(Cl)N=C1Cl
6-BROMO-2,4-DICHLOROQUINAZOLINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuff.
Synthese
The synthesis of 6-BROMO-2,4-DICHLOROQUINAZOLINE is as follows:BTC (0.65 g, 2.2 mmol in 6mL of PhCl) was added to astirred solution of tris(4-methoxyphenyl)phosphine oxide 3d(0.33 g, 0.9 mmol in 5mL PhCl) dropwise in a round botttomflask placed on an ice bath. After complete addition,the mixture was stirred for 30 min at room temperature.Then isatin-3-oximes (3 mmol) were added, and the mixturewas heated to 120 C until completion of the reaction(followed by TLC, n-hexane/ethyl acetate 10:1). Aftercooling, the mixture was then poured into 50mL ice waterand extracted with ethyl acetate (320 mL). The organiclayer was dried over anhydrous Na
2SO
4 and concentrated invacuo. The crude product was purified over column chromatography(n-hexane/ethyl acetate 10:1) to afford thepure produce 2,4-dichloroquinazolins. Tris(4-methoxyphenyl)phosphine oxide 3d was recovered by column chromatography(n-hexane/ethyl acetate 1:1).
6-BROMO-2,4-DICHLOROQUINAZOLINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
6-BROMO-2,4-DICHLOROQUINAZOLINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 157)Lieferanten
- 6-BROMO-2,4-DICHLOROQUINAZOLINE
- 6-Bromo-2,4-dichloroquina...
- 2,4-Dichloro-6-broMoquinazoline
- 4-dichloroquinazoline
- 6-broMo-2,4-dichlroquinazoline
- Quinazoline, 6-bromo-2,4-dichloro-
- 6-Bromo-2,4-dichloroquinazoline,97%
- 102393-82-8
- C8H3BrCl2N2
- CHIRAL CHEMICALS
