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Telomycin

Telomycin Struktur
19246-24-3
CAS-Nr.
19246-24-3
Bezeichnung:
Telomycin
Englisch Name:
Telomycin
Synonyma:
A-128;Nsc235069;Telomycin;Antibiotic 128;A 128-HYP, A 128-OP;18H-Dipyrrolo[2,1-C:2',1'-o][1,4,7,10,13,16,19,22,25]oxaoctaazacyclooctacosine;N-(L-βAsp-L-Ser-)Cyclo(L-Thr*-L-aThr-L-Ala-Gly-L-t3Hyp-3-(1H-indole-3-yl)Dha-β-methyl-L-Trp-4,4-dimethyl-L-aThr-L-c3Hyp-);L-Proline, L-β-aspartyl-L-seryl-L-threonyl-L-allothreonyl-L-alanylglycyl-(3S)-3-hydroxy-L-prolyl-α,β-didehydrotryptophyl-β-methyl-L-tryptophyl-(3S)-3-hydroxy-L-leucyl-3-hydroxy-, (11→3)-lactone, (3R)-;L-Proline, L-.beta.-aspartyl-L-seryl-L-threonyl-L-allothreonyl-L-alanylglycyl-trans-3-hydroxy-L-prolyl-erythro-3-hydroxy-L-leucyl-.beta.-methyl-L-tryptophyl-.alpha.,.beta.-didehydro-L-tryptophyl-cis-3-hydroxy-, .beta.1-lactone
CBNumber:
CB4882750
Summenformel:
C59H77N13O19
Molgewicht:
1272.33
MOL-Datei:
19246-24-3.mol

Telomycin Eigenschaften

alpha 
D28 -133° (c = 1 in 2:1 methanol-water)
Siedepunkt:
850.94°C (rough estimate)
Dichte
1.1263 (rough estimate)
Brechungsindex
1.6700 (estimate)
storage temp. 
Store at -20°C
L?slichkeit
DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble; Water: slightly soluble
Aggregatzustand
A solid
pka
2.41±0.10(Predicted)

Sicherheit

Toxizit?t LD50 in mice (mg/kg): >1000 orally, i.v., i.p., i.m. (Tisch)

Telomycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Telomycin is a complex, high molecular weight depsipeptide discovered in 1958. The structure was subsequently solved in 1968. Telomycin possesses potent and highly selective activity against Gram positive bacteria in vitro and in vivo when given by intramuscular administration. Telomycin is poorly absorbed after oral administration. Despite its structural novelty, telomycin has received little attention.

Telomycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Telomycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 21)Lieferanten
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Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684;
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ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
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Meng Cheng Technology (Shanghai) Co., LTD 400-820-6829
sales@mitachieve.com China 8860 58
  • Telomycin
  • N-(L-βAsp-L-Ser-)Cyclo(L-Thr*-L-aThr-L-Ala-Gly-L-t3Hyp-3-(1H-indole-3-yl)Dha-β-methyl-L-Trp-4,4-dimethyl-L-aThr-L-c3Hyp-)
  • 18H-Dipyrrolo[2,1-C:2',1'-o][1,4,7,10,13,16,19,22,25]oxaoctaazacyclooctacosine
  • A-128
  • Antibiotic 128
  • L-Proline, L-.beta.-aspartyl-L-seryl-L-threonyl-L-allothreonyl-L-alanylglycyl-trans-3-hydroxy-L-prolyl-erythro-3-hydroxy-L-leucyl-.beta.-methyl-L-tryptophyl-.alpha.,.beta.-didehydro-L-tryptophyl-cis-3-hydroxy-, .beta.1-lactone
  • Nsc235069
  • A 128-HYP, A 128-OP
  • L-Proline, L-β-aspartyl-L-seryl-L-threonyl-L-allothreonyl-L-alanylglycyl-(3S)-3-hydroxy-L-prolyl-α,β-didehydrotryptophyl-β-methyl-L-tryptophyl-(3S)-3-hydroxy-L-leucyl-3-hydroxy-, (11→3)-lactone, (3R)-
  • 19246-24-3
  • C59H77N13O19
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