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Trilostan

Trilostane Struktur
13647-35-3
CAS-Nr.
13647-35-3
Bezeichnung:
Trilostan
Englisch Name:
Trilostane
Synonyma:
Vetoryl;Desopan;modrenal;Modrefen;Trostan*;Win 24540;rilostane;Trilostan;TRILOSTANE;Modrastane
CBNumber:
CB4768762
Summenformel:
C20H27NO3
Molgewicht:
329.43
MOL-Datei:
13647-35-3.mol

Trilostan Eigenschaften

Schmelzpunkt:
264 °C
alpha 
D25 +137.4° (c = 1 in pyridine)
Siedepunkt:
467.02°C (rough estimate)
Dichte
1.1213 (rough estimate)
Brechungsindex
1.5614 (estimate)
storage temp. 
2-8°C
L?slichkeit
DMSO: ≥17mg/mL
Aggregatzustand
powder
pka
8.57±0.70(Predicted)
Farbe
white to tan
InChIKey
KVJXBPDAXMEYOA-CXANFOAXSA-N
SMILES
[C@@]123CC[C@@]4([H])[C@]5([H])CC[C@H](O)[C@@]5(C)CC[C@]4([H])[C@@]1(C)CC(C#N)=C(O)[C@@]2([H])O3 |&1:0,3,5,9,11,15,17,25,r|
CAS Datenbank
13647-35-3(CAS DataBase Reference)
EPA chemische Informationen
Trilostane (13647-35-3)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 36/37/38-62
S-S?tze: 26-36/37
WGK Germany  3
HS Code  29372900
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H361 Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. Reproduktionstoxizit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Trilostan Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

3β-hydroxysteroid dehydrogenase (3β-HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3β-HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3β-HSD2 (type 2) is expressed in the adrenal gland, ovary, and testis. Trilostane is an inhibitor of the 3β-HSDs: 3β-HSD1 and 3β-HSD2 with Ki values of 0.10 and 1.60 μM, respectively. Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels. Because human 3β-HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.

Chemische Eigenschaften

Tan Crystals

Verwenden

Trilostane has been used to evaluate its capability to regulate the sex-dependent differences in the lipopolysaccharide (LPS)-induced inflammatory responses of astrocytes.

Allgemeine Beschreibung

Trilostane inhibits the production of adrenal steroids, such as cortisol and aldosterone. It is used to treat aldosteronism.

Trilostan Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Trilostan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 360)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9315 58
Tianjin Kilo Pharmaceutical Sci-Tech Co., Ltd
+86-02223869539 +86-15560057295
trade.kilopharma@foxmail.com China 27 58
Liaoning Pharmaceutical Innovation Co., Ltd
+8616588669988
sales@pipharma.com.cn China 151 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5858 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Shaanxi Haibo Biotechnology Co., Ltd
+undefined18602966907
qinhe02@xaltbio.com China 997 58
Hebei Mojin Biotechnology Co.,Ltd
+86-15028179902
angelia@hbmojin.com China 1179 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
+86-18600796368 +86-18600796368
sales@sjar-tech.com China 375 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21639 55

13647-35-3(Trilostan)Verwandte Suche:


  • TRILOSTANE
  • (2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car
  • 17-beta)-ph
  • (4a,5a,17b)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
  • 5a-Androstane-2a-carbonitrile, 4a,5-epoxy-17b-hydroxy-3-oxo-
  • Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4a,5a,17b)-
  • 4α,5-Epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile
  • 4α,5-Epoxy-3,17β-dihydroxy-5α-androstan-2-ene-2-carbonitrile
  • Trilostane ,99%
  • modrenal
  • Win-24540,Desopan,Modrastane,Modrenal
  • 4,5-Epoxy-5H-cyclopenta[a]phenanthrene, androst-2-ene-2-carbonitrile deriv.
  • Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4a,5a,17b)- (9CI)
  • Desopan
  • Modrastane
  • Modrefen
  • Win 24540
  • (1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-diMethyl-7-oxapentacyclo[9.7.0.0^{2,8}.0^{6,8}.0^{12,16}]octadec-4-ene-4-carbonitrile
  • Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)-
  • (4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
  • 4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril
  • 4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile
  • 4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril
  • androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al
  • Trilostane(Win 24540
  • MODRASTANE; MODREFEN; MODRENAL; VETORYL; WIN 24540
  • Trilostane (Mixture of Tautomeric Isomers)
  • rilostane
  • Trilostane ISO 9001:2015 REACH
  • Trilostan
  • Vetoryl
  • Tralostatin
  • Trilostane/Win24540/Modrastane
  • (1aS,4aR,4bS,6aS,7S,9aS,9bS,11aR)-2,7-Dihydroxy-4a,6a-dimethyl-1a,4,4a,4b,5,6,6a,7,8,9,9a,9b,10,11-tetradecahydrocyclopenta[7,8]phenanthro[1,10a-b]oxirene-3-carbonitrile
  • Trostan*
  • Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)-
  • 13647-35-3
  • 3647-35-3
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • Inhibitor
  • FULVICIN
  • APIs
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