Trilostan
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- CAS-Nr.
- 13647-35-3
- Bezeichnung:
- Trilostan
- Englisch Name:
- Trilostane
- Synonyma:
- Vetoryl;Desopan;modrenal;Modrefen;Trostan*;Win 24540;rilostane;Trilostan;TRILOSTANE;Modrastane
- CBNumber:
- CB4768762
- Summenformel:
- C20H27NO3
- Molgewicht:
- 329.43
- MOL-Datei:
- 13647-35-3.mol
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Trilostan Eigenschaften
- Schmelzpunkt:
- 264 °C
- alpha
- D25 +137.4° (c = 1 in pyridine)
- Siedepunkt:
- 467.02°C (rough estimate)
- Dichte
- 1.1213 (rough estimate)
- Brechungsindex
- 1.5614 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: ≥17mg/mL
- Aggregatzustand
- powder
- pka
- 8.57±0.70(Predicted)
- Farbe
- white to tan
- InChIKey
- KVJXBPDAXMEYOA-CXANFOAXSA-N
- SMILES
- [C@@]123CC[C@@]4([H])[C@]5([H])CC[C@H](O)[C@@]5(C)CC[C@]4([H])[C@@]1(C)CC(C#N)=C(O)[C@@]2([H])O3 |&1:0,3,5,9,11,15,17,25,r|
- CAS Datenbank
- 13647-35-3(CAS DataBase Reference)
- EPA chemische Informationen
- Trilostane (13647-35-3)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H361 |
Kann vermutlich die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Reproduktionstoxizit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Trilostan Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
3β-
hydroxysteroid dehydrogenase (3β-
HSD) type 1 and type 2 isoforms are key enzymes for the biosynthesis of all active steroid hormones. 3β-
HSD1 (type I) is expressed in placenta and peripheral tissues including breast tumors, whereas 3β-
HSD2 (type 2) is expressed in the adrenal gland, ovary, and testis. Trilostane is an inhibitor of the 3β-
HSDs: 3β-
HSD1 and 3β-
HSD2 with K
i values of 0.10 and 1.60 μM, respectively. Trilsotane has been approved for use in the treatment of Cushing’s syndrome in dogs to reduce cortisol, aldosterone, and corticosterone levels. Because human 3β-
HSD (type 1) is a critical enzyme in the conversion of DHEA to estradiol in breast tumors, trilostane is also of interest for the treatment of breast cancer in postmenopausal women.
Chemische Eigenschaften
Tan Crystals
Verwenden
Trilostane has been used to evaluate its capability to regulate the sex-dependent differences in the lipopolysaccharide (LPS)-induced inflammatory responses of astrocytes.
Allgemeine Beschreibung
Trilostane inhibits the production of adrenal steroids, such as cortisol and aldosterone. It is used to treat aldosteronism.
Trilostan Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Trilostan Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 376)Lieferanten
13647-35-3(Trilostan)Verwandte Suche:
- TRILOSTANE
- (2-alpha,4-alpha,5-alpha,17-beta)-4,5-epoxy-17-hydroxy-3-oxoandrostane-2-car
- 17-beta)-ph
- (4a,5a,17b)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
- 5a-Androstane-2a-carbonitrile, 4a,5-epoxy-17b-hydroxy-3-oxo-
- Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4a,5a,17b)-
- 4α,5-Epoxy-3,17β-dihydroxy-5α-androst-2-ene-2-carbonitrile
- 4α,5-Epoxy-3,17β-dihydroxy-5α-androstan-2-ene-2-carbonitrile
- Trilostane ,99%
- modrenal
- Win-24540,Desopan,Modrastane,Modrenal
- 4,5-Epoxy-5H-cyclopenta[a]phenanthrene, androst-2-ene-2-carbonitrile deriv.
- Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4a,5a,17b)- (9CI)
- Desopan
- Modrastane
- Modrefen
- Win 24540
- (1S,2R,6R,8S,11S,12S,15S,16S)-5,15-dihydroxy-2,16-diMethyl-7-oxapentacyclo[9.7.0.0^{2,8}.0^{6,8}.0^{12,16}]octadec-4-ene-4-carbonitrile
- Androst-2-ene-2-carbonitrile, 4,5-epoxy-3,17-dihydroxy-, (4α,5α,17β)-
- (4α,5α,17β)-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
- 4-alpha,5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril
- 4-alpha,5-epoxy-3,17-dihydroxy-5-alpha-androst-2-ene-2-carbonitrile
- 4-alpha-5-epoxy-17-beta-hydroxy-3-oxo-5-alpha-androstane-2-alpha-carbonitril
- androstane-2-carbonitrile,4,5-epoxy-17-hydroxy-3-oxo-,(2-alpha,4-alpha,5-al
- Trilostane(Win 24540
- MODRASTANE; MODREFEN; MODRENAL; VETORYL; WIN 24540
- Trilostane (Mixture of Tautomeric Isomers)
- rilostane
- Trilostane ISO 9001：2015 REACH
- Trilostan
- Vetoryl
- Tralostatin
- Trilostane/Win24540/Modrastane
- (1aS,4aR,4bS,6aS,7S,9aS,9bS,11aR)-2,7-Dihydroxy-4a,6a-dimethyl-1a,4,4a,4b,5,6,6a,7,8,9,9a,9b,10,11-tetradecahydrocyclopenta[7,8]phenanthro[1,10a-b]oxirene-3-carbonitrile
- Trostan*
- Trilostane, 10 mM in DMSO
- Trilostane - Bio-X ?
- 13647-35-3
- 3647-35-3
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Steroids
- Inhibitor
- FULVICIN
- APIs
