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1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE

1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Struktur
688348-25-6
CAS-Nr.
688348-25-6
Englisch Name:
1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE
Synonyma:
PDM 2;PDM-2;PDM2;PDM 2;688348-25-6;(E)-1,3-Dichloro-5-(4-chlorostyryl)benzene;1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene;1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE;Benzene, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-;inhibit,Aryl Hydrocarbon Receptor,PDM2,PDM-2,PDM 2,Inhibitor,AhR
CBNumber:
CB4739467
Summenformel:
C14H9Cl3
Molgewicht:
283.58
MOL-Datei:
688348-25-6.mol

1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Eigenschaften

Siedepunkt:
394.2±42.0 °C(Predicted)
Dichte
1.360±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 2 mg/ml
Aggregatzustand
A crystalline solid
Farbe
White to off-white

Sicherheit

1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The aryl hydrocarbon receptor (AhR) is a ligand-dependent intracellular transcription factor whose ligands include some of the most infamous xenobiotics, including dioxin, benzo[a]pyrene, and numerous polyaromatics from soot and coal tar. PDM 2 is an analog of resveratrol acting as a potent and selective aryl hydrocarbon receptor (AhR) antagonist, with a Ki of 1.2 nM. PDM 2 is inactive as a ligand for the estrogen receptor even at 100 μM. As AhR knockout mice are insensitive to the carcinogenic effects of classical AhR ligands, PDM 2 is a potential therapeutic for the treatment for dioxin and other aryl hydrocarbon poisonings.

1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 1,3-DICHLORO-5-[(1E)-2-(4-CHLOROPHENYL)ETHENYL]-BENZENE
  • PDM 2
  • 1,3-dichloro-5-[(E)-2-(4-chlorophenyl)ethenyl]benzene
  • PDM-2;PDM2;PDM 2;688348-25-6
  • Benzene, 1,3-dichloro-5-[(1E)-2-(4-chlorophenyl)ethenyl]-
  • inhibit,Aryl Hydrocarbon Receptor,PDM2,PDM-2,PDM 2,Inhibitor,AhR
  • (E)-1,3-Dichloro-5-(4-chlorostyryl)benzene
  • 688348-25-6
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