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BISINDOLYLMALEIMIDE III

BISINDOLYLMALEIMIDE III Struktur
137592-43-9
CAS-Nr.
137592-43-9
Englisch Name:
BISINDOLYLMALEIMIDE III
Synonyma:
BISINDOLYLMALEIMIDE III;Bisindolylmaleimide III, PKC inhibitor;3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-
CBNumber:
CB4728487
Summenformel:
C23H20N4O2
Molgewicht:
384.43
MOL-Datei:
Mol file

BISINDOLYLMALEIMIDE III Eigenschaften

Siedepunkt:
708.7±60.0 °C(Predicted)
Dichte
1.41±0.1 g/cm3(Predicted)
L?slichkeit
DMSO: soluble; Methanol: soluble
Aggregatzustand
A crystalline solid
pka
8.15±0.60(Predicted)
Farbe
Brown to reddish brown

Sicherheit

BISINDOLYLMALEIMIDE III Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Bisindolylmaleimide III was developed as a protein kinase C (PKC) inhibitor with structural similarity to the nonspecific PKC inhibitor staurosporine. At 1 μM, bisindolylmaleimide III inhibits 93% of PKCα kinase activity and also inhibits many other protein kinases including, S6K1, MAPKAP-K1, RSK2 and MSK1 with similar potency. Additionally, it inhibits PDK1, an important kinase in the insulin signaling pathway, with an IC50 value of 3.8 μM.

Verwenden

Bisindolylmaleimide III is a protein kinase C inhibitor and was also shown to exhibit inhibitory activities towards PDK1, an important kinase in the insulin signaling pathway,

BISINDOLYLMALEIMIDE III Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

BISINDOLYLMALEIMIDE III Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • BISINDOLYLMALEIMIDE III
  • 3-[1-(3-aminopropyl)indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
  • 1H-Pyrrole-2,5-dione, 3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1H-indol-3-yl)-
  • 3-(1-(3-Aminopropyl)-1H-indol-3-yl)-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione
  • Bisindolylmaleimide III, PKC inhibitor
  • 137592-43-9
  • Amines, Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
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