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KNK437

KNK437 Struktur
218924-25-5
CAS-Nr.
218924-25-5
Englisch Name:
KNK437
Synonyma:
KNK437;KNK423;CS-1681;KNK-437;KNK 437;HEAT SHOCK PROTEIN INHIBITOR I;HEAT SHOCK PROTEIN INHIBITOR II;KNK 437 (Heat Shock Protein Inhibitor I);3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM;N-Formyl-3,4-methylenedioxy-benzylidene-g-butyrolactam;N-FORMYL-3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM
CBNumber:
CB4713272
Summenformel:
C13H11NO4
Molgewicht:
245.23
MOL-Datei:
Mol file

KNK437 Eigenschaften

Siedepunkt:
412.4±55.0 °C(Predicted)
Dichte
1.515±0.06 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
DMSO: soluble5mg/mL, clear (warmed)
Aggregatzustand
White to light yellow powder
pka
-1.70±0.20(Predicted)
Farbe
white to beige
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Sicherheit

WGK Germany  3

KNK437 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

KNK437 has been used:
  • as a heat shock factor 1 (HSF1) inhibitor to study its effects on the inhibition of viability and apoptosis activation in chemoresistant mice cells
  • as an HSF1 inhibitor to study its effects on viability and apoptosis of colorectal cancer cells
  • as a heat shock protein 70 (HSP70) inhibitor to study its effects on glutamine-induced HSP70 and inflammatory mediator release

Biochem/physiol Actions

KNK437 inhibits the accumulation of heat shock proteins (including hsp -27, -40, -70, -72 and -105). KNK437 inhibits thermotolerance in cells with greater potency than quercetin.

KNK437 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

KNK437 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 80)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 		+86-021-61551413 +8618813727289
 contact@trustwe.com China 5738 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 		+86-86-22-87899925 +86-8618522618860
 18522618860@163.com China 694 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Henan Fengda Chemical Co., Ltd 		+86-371-86557731 +86-13613820652
 info@fdachem.com China 20284 58

218924-25-5()Verwandte Suche:

  • N-FORMYL-3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM
  • 3,4-METHYLENEDIOXY-BENZYLIDINE-GAMMA-BUTYROLACTAM
  • KNK423
  • KNK437
  • HEAT SHOCK PROTEIN INHIBITOR I
  • HEAT SHOCK PROTEIN INHIBITOR II
  • 3-(1,3-Benzodioxol-5-ylmethylene)-2-oxo-1-pyrrolidinecarboxaldehyde
  • Heat Shock Protein Inhibitor I - CAS 218924-25-5 - Calbiochem
  • CS-1681
  • 3-[(E)-1,3-Benzodioxol-5-ylmethylene]-2-oxopyrrolidine-1-carbaldehyde
  • KNK-437;KNK 437
  • 1-Pyrrolidinecarboxaldehyde, 3-(1,3-benzodioxol-5-ylmethylene)-2-oxo-
  • N-Formyl-3,4-methylenedioxy-benzylidene-g-butyrolactam
  • 3-(Benzo[d][1,3]dioxol-5-ylmethylene)-2-oxopyrrolidine-1-carbaldehyde
  • HSP,inhibit,Heat shock proteins,KNK-437,KNK437,KNK 437,Inhibitor
  • KNK 437 (Heat Shock Protein Inhibitor I)
  • 218924-25-5
  • API
  • Inhibitors
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