ANTI-CASPASE-12
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ANTI-CASPASE-12 Eigenschaften
- storage temp.
- −20°C
- Aggregatzustand
- buffered aqueous solution
- Biologische Quelle
- rat
Sicherheit
ANTI-CASPASE-12 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Monoclonal Anti-Caspase 12 has been used in immunoblotting and immunocytochemistry (4% paraformaldehyde-fixed, paraffin-embedded).Allgemeine Beschreibung
Caspase 12 is a protein that belongs to a family of enzymes called caspases that cleave their substrates at C-terminal aspartic acid residues. The human caspase 12 gene is localized at a single locus within the caspase 1/ICE gene cluster on chromosome 11q22. The functionality is lost in humans and they cannot play a role in Alzheimer′s disease. Caspase-12 is detected in endoplasmic reticulum (ER), plays a role in ER-mediated apoptosis and inflammatory caspase activation pathway.Biochem/physiol Actions
Murine caspase 12 (CASP12) is activated during endoplasmic reticulum stress and activates other caspases which act on substrates, ultimately leading to apoptosis. The protein has been shown to be activated during progression of retinal degeneration in animal models. In mice models, CASP12 has been shown to cause neuronal death resulting from ischemia/reperfusion. Casp12 might stimulate nuclear factor-κB (NF-κB) by directing the post-translational degradation of inhibitor of kappa B (IκBα). Overexpression of caspase 12 induces apoptosis, which is inhibited by the pan caspase inhibitor carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethyl ketone (z-VAD-FMK).ANTI-CASPASE-12 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ANTI-CASPASE-12 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 6)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Riedel-de Haen AG | -- |
United States | 6773 | 87 | |
SIGMA-RBI | -- |
Switzerland | 6896 | 91 | |
Kamiya Biomedical Company | -- |
ordering@kamiyabiomedical.com | United States | 736 | 72 |
Fluorochem Ltd. | -- |
enquiries@fluorochem.co.uk | United Kingdom | 6401 | 74 |
BD Biosciences | -- |
United States | 5013 | 82 | |
MP Biomedicals, Inc. | -- |
United States | 6561 | 81 |
- Anti-Caspase-12 (large) antibody produced in rabbit
- Anti-Caspase-12 (small) antibody produced in rabbit
- ANTI-CASPASE-12
- ANTISERUM TO CASPASE-12 (NT)
- POLYCLONAL ANTIBODY TO CASPASE-12 (NT)
- MONOCLONAL ANTI-CASPASE 12
- Monoclonal Anti-Caspase 12 antibody produced in rat
- 1
- Alphabetical Index
- Antibodies
- Antibodies to Caspases
- Apoptosis Enzymes
- Clone Index
- C1 to CACell Signaling Enzymes
- Caspase 11, 12, and 13Antibodies for Apoptosis
- Caspase 12Antibodies