POLY-L-HISTIDINE HYDROCHLORIDE MW Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Poly-L-histidine has been used:
- as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs)
- as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membrane
- in screening its anti-prion activity in cell based and in vivo anti-prion assay
Allgemeine Beschreibung
Poly-L-histidine is an amphoteric compound. The imidazole ring in its structure enables protonation?deprotonation.
Biochem/physiol Actions
Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)?poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.
POLY-L-HISTIDINE HYDROCHLORIDE MW Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
