OSI-420 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Desmethyl erlotinib is a metabolite of erlotinib . Erlotinib is a tyrosine kinase inhibitor which acts on the epidermal growth factor receptor (EGFR), inhibiting EGFR-associated kinase activity (IC₅₀ = 2.5 μM). This inhibits tumor growth in human head and neck carcinoma HN5 tumor xenografts in mice with an ED₅₀ value of 9 mg/kg. Erlotinib also suppresses cyclin-dependent kinase 2 (Cdk2) activity in breast cancer cells (IC₅₀ = 4.6 μM) and JAK2 mutant JAK2^V617F positive hematopoietic progenitor cells (IC₅₀ = 5 μM), which is associated with polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia. Formulations containing erlotinib have been used to treat certain forms of cancer, including non-small cell lung cancer.

Chemische Eigenschaften

Off-White Solid

Verwenden

OSI-420 (Desmethyl Erlotinib,CP-473420) is an active metabolite of erlotinib which is an orally active EGFR tyrosin kinase inhibitor with IC50 of 2 and 20 nM for the inhibition of human EGFR and EGFR autophosphorylation in tumor cells.

OSI-420 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

OSI-420 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	965	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28172	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32024	58
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	laboratory@coreychem.com	China	30241	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6312	58
Hangzhou Huarong Pharm Co., Ltd.	571-86758373 +8613588754946	sales@huarongpharm.com	CHINA	3148	58
Labnetwork lnc.	+86-27-50766799 +8618062016861	contact@labnetwork.com	China	19987	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38463	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58

183321-86-0()Verwandte Suche:

---

• CP 373420
• OSI-420 (free base)
• Erlotinib O-DesMethyl Metabolite
• Erlotinib iMpurity H
• Desmethyl Erlotinib (CP-473420, OSI-420)
• 6-O-Desmethyl Erlotinib 1
• 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol
• 2-((4-((3-Ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethanol
• OSI-420
• ROSCOVITINE(CVC202)
• Erlotinib-10
• Erlotinib 6-O-Desmethyl Metabolite
• Erlotinib Hydrochloride iMpurity 9
• 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)
• OSI-420 impurity
• Erlotinib O-Desmethyl Metabolite Isomer
• 2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quizolin-6-yl)oxy)ethan-1-ol
• 6-O-Desmethyl Erlotinib
• Erlotinib impurity J
• Erlotinib impurity N
• Erlotinib O-Desmethyl Metabolite Isomer (M14)
• Erlotinib impurity 16/Desmethyl Erlotinib/2-((4-((3-ethynylphenyl)amino)-7-(2-methoxyethoxy)quinazolin-6-yl)oxy)ethan-1-ol
• Desmethyl Erlotinib (CP-473420, OSI-774)
• Ethanol, 2-[[4-[(3-ethynylphenyl)amino]-7-(2-methoxyethoxy)-6-quinazolinyl]oxy]-
• Erlotinib impurities405
• Azilsartan medoxomil impurity247
• Erlotinib O-Desmethyl Metabolite (M14)
• β-Amyloid (1-42)
• Erlotinib Impurity 167
• 183321-86-0
• Inhibitors
• Intermediates & Fine Chemicals
• Metabolites & Impurities
• Pharmaceuticals
• Heterocycles