NS 3694
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NS 3694 Eigenschaften
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: 22 mg/mL, soluble
- Aggregatzustand
- solid
- Farbe
- Off-white to light yellow
Sicherheit
WGK Germany | 3 |
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NS 3694 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Cytochrome c, which leaks from the mitochondrial intermembrane space into the cytosol, causes oligomerization of apoptotic protease-activating factor 1 (Apaf-1), forming a caspase activation complex known as the apoptosome. NS3694 is a cell-permeable diarylurea compound that inhibits apoptosome formation and caspase activation. It blocks cytochrome c-induced caspase activation in HeLa cell cytosolic extracts with an IC50 value of approximately 50 μM. NS3694 prevents the formation of apoptosomes, which prevents the association of procaspases with Apaf-1. It suppresses caspase activation and apoptosis in cells treated with either TNF-α or staurosporine . NS3694 is used to examine the role of apoptosome-mediated caspase activation in cell death.Verwenden
NS3694 is a suppressor of the formation of apoptosome Apaf-1.NS 3694 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
NS 3694 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 33)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 |
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30236 | 58 |
Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 |
sales@molcore.com | China | 49734 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52924 | 58 |
VDM Biochemicals | 0330-2528181 |
sales@vdmbio.com | United States | 510 | 64 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9806 | 58 |
Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 |
klq@cw-bio.com | China | 5944 | 55 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11218 | 58 |
MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 |
order@med-bio.cn | China | 8140 | 58 |
Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44918 | 58 |
426834-38-0()Verwandte Suche:
- Apoptosis Inhibitor II, NS3694
- Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem
- Benzoic acid, 4-chloro-2-[[[[3-(trifluoromethyl)phenyl]amino]carbonyl]amino]-
- NS 3694,Inhibitor,Apaf-1,Apoptosis,inhibit,caspase-9,NS-3694,apoptosome inhibitor,NS3694,cytochrome c
- NS3694, 10 mM in DMSO
- 426834-38-0
- C15H10ClF3N2O3
- Apoptosis Inhibitors