Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A MAC (Mitochondrial Apoptosis-induced Channel) inhibitor iMAC1 (Cat. No. 196805) structural analog that is reported to be less potent than iMAC1 in blocking Bid-induced cytochrome c release in cell-free mitochondria preparations (40% vs. 77% inhibition with 5 μM respective inhibitor), but more effective than iMAC1 in inhibiting STS- (Cat. No. 569396 & 569397) induced cytochrome c release in intact FL5.12 cells (Complete vs ~35% inhibition with 5 μM respective inhibitor), presumably due to an enhanced permeability. iMAC2 is also shown to be a superior blocker of MAC-mediated current flow in reconstituted mitochondrial outer membrane patches from apoptotic FL5.12 cells (IC₅₀ = 28 vs 300 nM in the case of iMAC2 and iMAC1, respectively) and protect FL5.12 from STS-induced apoptosis (IC₅₀ = 2.5 μM).

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
TargetMol Chemicals Inc.	15002134094	marketing@targetmol.cn	China	19700	58

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• Bax Channel Blocker II, iMAC2 - CAS 335166-00-2 - Calbiochem
• iMAC2 hydrochloride
• 335166-00-2