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FLURITHROMYCIN

FLURITHROMYCIN Struktur
82664-20-8
CAS-Nr.
82664-20-8
Englisch Name:
FLURITHROMYCIN
Synonyma:
cl-932;p80206;C1-932;P-0501-A;FLURITHROMYCIN;fluritromicina;antibioticp80206;Huritromicina(sp);8-fluoro-erythromyci;8-fluoroerythromycin
CBNumber:
CB4467319
Summenformel:
C37H66FNO13
Molgewicht:
751.92
MOL-Datei:
82664-20-8.mol

FLURITHROMYCIN Eigenschaften

Schmelzpunkt:
>139°C (dec.)
Siedepunkt:
814.6±65.0 °C(Predicted)
Dichte
1.22±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
L?slichkeit
Chloroform (Slightly), DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
Aggregatzustand
Solid
pka
12.94±0.70(Predicted)
Farbe
White to Off-White

Sicherheit

Kennzeichnung gef?hrlicher F
R-S?tze: 10
S-S?tze: 16

FLURITHROMYCIN Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R10:Entzündlich.

S-S?tze Betriebsanweisung:

S16:Von Zündquellen fernhalten - Nicht rauchen.

Verwenden

A fluorinated derivative of Erythromycin (E649950). A macrolide antibiotic.

Definition

ChEBI: An erythromycin derivative that is erythromycin A in which the hydrogen attached to the carbon at position 8 (alpha to the ketone carbonyl group) has been replaced by a fluorine. It has been used (generally as the corresponding monoethyl s ccinate ester) as an antibacterial drug.

Pharmazeutische Anwendungen

A semisynthetic derivative of erythromycin A, supplied for oral administration. It is stable at acid pH due to the presence of the fluorine atom at C-8 of the erythronolide A ring.
It is active against most streptococci (including Str. pneumoniae and Str. agalactiae; MIC50 0.03 mg/L), Mor. catarrhalis, N. gonorrhoeae (MIC50 0.04 mg/L), C. trachomatis (MIC 0.06– 0.125 mg/L), M. genitalium (MIC50 0.007 mg/L) and U. urealyticum (MIC50 0.03 mg/L). It has little or no activity against H. influenzae and M. hominis. Activity against anaerobes is similar to that of erythromycin A. It displays cross-resistance with erythromycin A.
A single 500 mg oral dose achieved a mean peak plasma concentration of 1.2–2 mg/L after 1–2 h. The apparent elimination half-life was 8 h and the volume of distribution 5.5 L/ kg. With repeated doses (500 mg orally every 8 h for 10 doses), plasma concentrations were 0.72 mg/L immediately before and 0.67 mg/L at 4 h after the last dose. Absorption is not significantly affected by food. After administration of a single 375 mg tablet of flurithromycin ethylsuccinate, the mean serum levels at 0.5 h were 0.43 ± 0.35 mg/L. The mean peak serum concentration (1.41 ± 0.49 mg/L) was achieved at 1 h. At 8 and 12 h, the serum levels were 0.14 (± 0.05) and 0.04 (± 0.04) mg/L, respectively. The apparent elimination half-life is 3.94 (± 1.42) h. The apparent half-life in artificial gastric juice was about 40 min.
It is generally well tolerated and has been used successfully for the treatment of lower respiratory tract infections. Availability is limited.

FLURITHROMYCIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


FLURITHROMYCIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 25)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-87569262 +86-15319487004
1015@dideu.com China 3209 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
jkinfo@jkchemical.com China 94657 76
Chemsky (shanghai) International Co.,Ltd 021-50135380
shchemsky@sina.com China 15402 60
Shenzhen Polymeri Biochemical Technology Co., Ltd. +86-400-002-6226 +86-13028896684;
sales@rrkchem.com China 57423 58
BOC Sciences 16314854226
inquiry@bocsci.com United States 9713 58
Zhejiang Huida Biotech Co., LTD 0571-89903882 13626641628
jiangnan@huidabiotech.com China 3656 58
Energy Chemical 021-58432009 400-005-6266
marketing@energy-chemical.com China 44918 58

82664-20-8()Verwandte Suche:


  • (8s)-8-fluoroerythromycina
  • 8-fluoro-erythromyci
  • 8-FluoroerythroMycin A
  • 8-fluoroerythromycin
  • antibioticp80206
  • cl-932
  • fluritromicina
  • p80206
  • FLURITHROMYCIN
  • C1-932
  • Huritromicina(sp)
  • P-0501-A
  • Erythromycin, 8-fluoro- (9CI)
  • FLURITHROMYCIN USP/EP/BP
  • 82664-20-8
  • C37H66NO13F
  • C37H66FNO13
  • Carbohydrates & Derivatives
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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