3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID
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- CAS-Nr.
- 53985-49-2
- Englisch Name:
- 3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- Synonyma:
- 3-Chloro-5-carboxybenzotrifluoride;3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID;Benzoic acid, 3-chloro-5-(trifluoromethyl)-;3-Carboxy-5-chlorobenzotrifluoride, 5-Chloro-alpha,alpha,alpha-trifluoro-m-toluic acid
- CBNumber:
- CB4435008
- Summenformel:
- C8H4ClF3O2
- Molgewicht:
- 224.56
- MOL-Datei:
- 53985-49-2.mol
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3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Eigenschaften
- Schmelzpunkt:
- 98-101℃
- Siedepunkt:
- 263℃
- Dichte
- 1.523
- Flammpunkt:
- 113℃
- storage temp.
- Sealed in dry,Room Temperature
- Wasserl?slichkeit
- Soluble in water.
- CAS Datenbank
- 53985-49-2
3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
2-Chloro-5-(trifluoromethyl)benzoic acid may be used as surrogate standard to investigate the exposure and home contamination in urine and hand wipe samples collected from farmers.
Synthese
A solution of tBuONO (35.2 g) and CuCl (38.6 g) in CH3CN (375 mL) was warmed to 45-50° C. The compound (50.0 g) obtained in step 2 was added slowly while cooling the reaction mixture to maintain 45-50° C. After stirring at 50° C. for 30 min, the mixture was cooled to 10° C. 6N Hydrochloric acid (250 mL) was added and the mixture was stirred for 10 min. The resultant product was extracted twice with ethyl acetate. The organic layer was-washed with 10% aqueous citric acid solution and water and dried, and the solvent was evaporated under reduced pressure. The obtained residue was purified by silica gel column chromatography (solvent gradient; 10→25% ethyl acetate/hexane) to give 3-chloro-5-(trifluoromethyl)benzoic acid (33.1 g, 60%) as a white powder.
3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 103)Lieferanten
- 3-CHLORO-5-(TRIFLUOROMETHYL)BENZOIC ACID
- 3-Chloro-5-carboxybenzotrifluoride
- 3-Carboxy-5-chlorobenzotrifluoride, 5-Chloro-alpha,alpha,alpha-trifluoro-m-toluic acid
- Benzoic acid, 3-chloro-5-(trifluoromethyl)-
- 53985-49-2
