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Pentagastrin

PENTAGASTRIN Struktur
5534-95-2
CAS-Nr.
5534-95-2
Bezeichnung:
Pentagastrin
Englisch Name:
PENTAGASTRIN
Synonyma:
GRP;ay6608;ici50123;petavlon;peptavlon;petogasrin;lanineamide;PENTAGASTRIN;Pehtagastrin;gastrodiagnost
CBNumber:
CB4412263
Summenformel:
C37H49N7O9S
Molgewicht:
767.9
MOL-Datei:
5534-95-2.mol

Pentagastrin Eigenschaften

Schmelzpunkt:
229-230° (dec)
alpha 
D22 -28.8 ±0.5° (DMF)
Siedepunkt:
1196.6±65.0 °C(Predicted)
Dichte
1.303±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%).
Aggregatzustand
powder
pka
4.19±0.10(Predicted)
Farbe
White to off-white
Sequenz
N-t-Boc-β-Ala-Trp-Met-Asp-Phe-NH2
InChIKey
NEYNJQRKHLUJRU-DZUOILHNSA-N
SMILES
C(C1=CNC2C=CC=CC1=2)[C@H](NC(=O)CCNC(=O)OC(C)(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N)CC1C=CC=CC=1 |&1:10,27,35,43,r|

Sicherheit

Kennzeichnung gef?hrlicher T
R-S?tze: 61-36/38-20/21
S-S?tze: 53-45-36/37/39-22
WGK Germany  1
RTECS-Nr. AY2970000
Giftige Stoffe Daten 5534-95-2(Hazardous Substances Data)

Pentagastrin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R61:Kann das Kind im Mutterleib sch?digen.
R36/38:Reizt die Augen und die Haut.
R20/21:Gesundheitssch?dlich beim Einatmen und bei Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.

Beschreibung

Pentagastrin is a synthetic polypeptide and cholecystokinin-2 (CCK2) receptor agonist. It binds selectively to CCK2 receptors in guinea pig brain over CCK1 receptors in rat pancreas (IC50s = 11 and 1,100 nM, respectively). Pentagastrin increases calcium influx and polyphosphoinositide turnover in rat GH3 pituitary cells (EC50s = 23 and 3.9 nM, respectively). It also increases histidine decarboxylase activity in mucous- and endocrine cell-enriched isolated rabbit fundic mucosal cells (EC50 = 2.9 nM). Pentagastrin induces contraction of isolated pig ileum smooth muscle cells in vitro (EC50 = 30 pM). It increases gastric acid and pepsin secretion in conscious cats in vivo (ED50s = 1.29 and 57.3 nmol/kg2 per hour, respectively). Formulations containing pentagastrin have previously been used as a diagnostic aid to evaluate gastric acid secretory function.

Chemische Eigenschaften

A white or almost white powder.

Verwenden

Pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor, and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test.

Allgemeine Beschreibung

Pentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH2), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.
Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.

Pentagastrin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

β-Alanin N-[(tert-Butoxy)carbonyl]-D-tryptophan Protective agent Propionamid L-ASPARTIC ACID

Downstream Produkte

Pentagastrin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 181)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shandong Huizhihan Supply Chain Co., Ltd
+8613363081709
 3957328362@qq.com China 300 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152
 Mandy@hangyubiotech.com China 10986 58
Shanghai Getian Industrial Co., LTD 		+86-15373193816 +86-15373193816
 mike@ge-tian.com China 269 58
American HealthyMorph LLC 		+8613363867578
 13363867578@163.com China 150 58
Hangzhou FandaChem Co.,Ltd. 		+8615858145714
 FandaChem@Gmail.com China 8778 55
Rixing Chemical CO.,LTD 		+86-13237129059 -13237129059
 sales@rixingchemi.com CHINA 229 55
career henan chemical co 		+86-0371-86658258 +8613203830695
 sales@coreychem.com China 29880 58
Beijing Yibai Biotechnology Co., Ltd 		0086-182-6772-3597
sales04@yibaibiotech.com CHINA 419 58
Chongqing Chemdad Co., Ltd 		+86-023-6139-8061 +86-86-13650506873
 sales@chemdad.com China 39894 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58

5534-95-2(Pentagastrin)Verwandte Suche:

  • T-BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2
  • aspartyl]-l-phenylalaninamide
  • ay6608
  • boc-beta-ala-try-met-asp-phe(nh2)
  • gastrodiagnost
  • ici50123
  • lanineamide
  • l-methionyl-l-alpha-aspartyl-
  • l-n-tert-butyleste
  • n-((1,1-dimethylethoxy)carbonyl)-beta-alanyl-l-tryptophyl-l-phenylalaninamid
  • petogasrin
  • -tert-butylester
  • ylpropionamido]-4-(methylthio)butyramido]succinamicacidn-tert-butylester
  • n-t-boc-β-ala-trp-met-asp-phe amide
  • N-T-boc-B-ala-trp-met-asp-phe amide
  • PENTAGASTRIN (ICI 50123) SYNTHETIC >99%
  • BOC-β-Ala-Trp-Met-Asp-Phe-NH2
  • N-(1,1-Dimethylethoxy)carbonyl-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2
  • N-Boc-βAla-L-Trp-L-Met-L-Asp-L-Phe-NH2
  • AY 6608, ICI 50123, NSC 367746, Boc-(b-Ala13)-Gastrin (13-17), Boc-b-Ala-CCK-4
  • Boc-b-Ala-Trp-Met-Asp-Phe-NH2
  • n-(alpha-carbamoylphenethyl)-3-[2-[2-[3-(carboxyamino)propionamido]-3-indol-3-
  • n-[n-[n-[n-(n-tert-butoxycarbonyl-beta-alanyl)-l-tryptophanyl]-l-methionyl]-l-
  • n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-alaninamid
  • n-carboxy-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartylphenyl-l-alaninamiden
  • n-t-butyloxycarbonyl-beta-alanyl-l-tryptophyl-l-methionyl-l-aspartyl-l-phenyla
  • peptavlon
  • petavlon
  • Boc-(β-Ala13)-Gastrin (13-17)
  • GRP
  • GASTRIN RELEASING PEPTIDE
  • BOC-BETA-ALA-TRP-MET-ASP-PHE-NH2
  • PENTAGASTRIN
  • N-T-BOC-BETA-ALA-TRP-MET-ASP-PHE AMIDE
  • Acetyl-L-glutamic acid &gamma
  • Z-N-methyl-L-glutamic acid &gamma
  • N-(Benzyloxycarbonyl)-L-glutamic Acid &alpha
  • Fmoc-L-alpha-aminoadipic acid &delta
  • Fmoc-N-methyl-L-glutamic acid &gamma
  • Methotrexate &alpha
  • 3-7-Cholecystokinin-7(swine), 3-[N-[(1,1-dimethylethoxy)carbonyl]-b-alanine]- (9CI)
  • L-Glutamic Acid &alpha
  • DL-Glutamic acid &gamma
  • N-tert-Butyloxycarbonyl-L-aspartic Acid &beta
  • Pentagastrin, ≥95%(HPLC)
  • Z-L-beta-Glutamic acid &gamma
  • Fmoc-L-aspartic Acid &beta
  • Pehtagastrin
  • L-Phenylalaninamide, N-[(1,1-dimethylethoxy)carbonyl]-β-alanyl-L-tryptophyl-L-methionyl-L-α-aspartyl-
  • PENTAGASTRIN USP/EP/BP
  • Boc-(β-Ala13)-Gastrin (13-17)
  • (10S,13S,16S)-10-((1H-Indol-3-yl)methyl)-16-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-2,2-dimethyl-13-(2-(methylthio)ethyl)-4,8,11,14-tetraoxo-3-oxa-5,9,12,15-tetraazaoctadecan-18-oic acid
  • 5534-95-2
  • C37H49N7O9S
  • C37H50N7O9S
  • Gastrointestinal Products
  • Cholecystokinins
  • Peptides
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